Safety and Efficacy of a Fish-Oil–Based Fat Emulsion in the Treatment of Parenteral Nutrition–Associated Liver Disease

Abstract

Parenteral fish-oil-based fat emulsions are safe and may be effective in the treatment of parenteral nutrition-associated liver disease.

Use of Parenteral Fish Oil to Reverse Cholestasis Induced by Parenteral Nutrition in Infants with Intestinal Failure: Single-Centre Case Series

“…In a previous study, the use of parenteral fish oil in a small subset of patients resulted in a shorter time to reversal of cholestasis relative to patients who received soybean oil emulsion, with no difference in essential fatty acid levels or infection rates. 3 In the study reported here, the use of parenteral fish oil reversed parenteral nutrition-induced cholestasis in all 8 patients over a median period of 18.6 weeks. The median time to normalization in previously published reports has ranged from 8 weeks to 8 months.…”

“…The median time to normalization in previously published reports has ranged from 8 weeks to 8 months. 2,3,5 In 2 patients, serum bilirubin levels normalized without enteral nutrition (patients E and H; This single copy is for your personal, non-commercial use only. For permission to reprint multiple copies or to order presentation-ready copies for distribution, contact CJHP at cjhpedit@cshp.ca Table 2), which correlates with previously reported results.…”

“…[1][2][3] Until recently, children requiring long-term parenteral nutrition who experienced parenteral nutrition-associated liver disease (PNALD) were likely to die from infection or liver disease before receiving a small bowel and/or liver transplant. 4 With the introduction of parenteral fish oil (10% long-chain omega-3 fatty acid emulsion; Omegaven, Fresenius Kabi, Bad Homburg, Germany), originally indicated for use in combination with a soybean oil-based lipid emulsion (Intralipid), we have been able to reverse this life-threatening condition in several infants without the need for transplantation.…”

Inhibition of neuroblastoma cell proliferation with omega-3 fatty acids and treatment of a murine model of human neuroblastoma using a diet enriched with omega-3 fatty acids in combination with sunitinib

“…Because prolonged administration of high levels of ω-3 FAs in children is safe (24,25), we propose that ω-3 FAs may be effective in the combination treatment of neuroblastoma.…”

Impact of New-Generation Parenteral Lipid Emulsions in Pediatric Nutrition

“…Multiple reports describing case series of infants with PNALD treated with Omegaven exist. Omegaven has been provided to several hundred, possibly more than 1000, infants in the United States and an unknown number of infants in other countries throughout the world (4,5).…”