Safety and Efficacy of 2 Intracavernous Injections of Allogeneic Wharton’s Jelly-Derived Mesenchymal Stem Cells in Diabetic Patients with Erectile Dysfunction: Phase 1/2 Clinical Trial

Demour, Saddam Al; Adwan, Sofia; Jafar, Hanan; Rahmeh, Reem; Alhawari, Hussam; Awidi, Abdalla

doi:10.1159/000517364

Cited by 19 publications

(5 citation statements)

References 28 publications

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“…In the second, the use of two consecutive ICI of WJSC was explored for the first time in a total sample of 22 diabetic patients with ED. Positive results regarding tolerability, safety and efficacy measured via IIEF-15 and EHS questionnaires and duplex doppler penile ultrasound imaging (DPE) were observed at the 12-month follow-up [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment

Pérez-Aizpurua

Garranzo-Ibarrola

Simón-Rodríguez

et al. 2023

Life

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Background: The improvement of absent or partial response in the medical treatment of erectile dysfunction (ED) has led to the development of minimally invasive new treatment modalities in the field of regenerative medicine. Methods: A literature review on stem cell therapy for the treatment of ED was performed. We searched for the terms “erectile dysfunction” and “stem cell therapy” in PubMed and Clinicaltrials.gov. Literature searching was conducted in English and included articles from 2010 to 2022. Results: New treatment modalities for ED involving stem cell therapy are not only conceived with a curative intent but also aim to avoid unnecessary adverse effects. Several sources of stem cells have been described, each with unique characteristics and potential applications, and different delivery methods have been explored. A limited number of interventional studies over the past recent years have provided evidence of a safety profile in their use and promising results for the treatment of ED, although there are not enough studies to generate an appropriate protocol, dose or cell lineage, or to determine a mechanism of action. Conclusions: Stem cell therapy is a novel treatment for ED with potential future applications. However, most urological societies agree that further research is required to conclusively prove its potential benefit.

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Section: Resultsmentioning

confidence: 99%

Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment

Pérez-Aizpurua

Garranzo-Ibarrola

Simón-Rodríguez

et al. 2023

Life

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“…They all indicated that it improved EF while remaining well-tolerated and safe. Two tests found that peak systolic velocity (PSV) increased significantly [ 35 , 60 ], in the contrary, it was not apparent in these two [ 61 , 62 ]. Yiou R et al [ 35 ] demonstrated the %PNORT is improved, implying the recovery of vascular endothelial function.…”

Section: Discussionmentioning

confidence: 99%

Vascular endothelium is the basic way for stem cells to treat erectile dysfunction: a bibliometric study

Zou

Chen

et al. 2023

Cell Death Discov.

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Vascular endothelial is considered to be a key factor in the pathogenesis of erectile dysfunction (ED). The purpose is to reveal the research trend of the field of ED and vascular endothelium. In addition, the goal is to discover the role and mechanism of vascular endothelium in ED. Bibliometrics and visualization methods based on CiteSpace were selected. We conducted the co-authorship analysis of countries, institutions and authors, co-occurrence analysis of keywords, and co-citation analysis of literature and authors through CiteSpace 6.1.R3. 1431 articles from Web of Science Core Collection (WOSCC) were included in the analysis from 1991 to 2022. We found some influential and cutting-edge nodes in each map, including countries, institutions, authors, articles, etc. Stem cell, therapy, oxidative stress, cavernous nerve injury, radical prostatectomy, fibrosis, erectile function, mesenchymal stem cell, and apoptosis may be hot keywords. In conclusion, the efficacy and mechanisms of stem cells and their derivatives in the treatment of diabetes (DM) ED and cavernous nerve injury (CNI) ED are the future research trends. Stem cells therapy for ED is a hot spot in this field, which side notes that stem cells may work mainly through improving endothelial function. Vascular endothelial cells and VEGF may repair nerve and cavernous smooth muscle directly or indirectly, and finally polish up erectile function.

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“… Mirzaei et al [ 89 ] (2021) 20 DMED 63.8 ± 7.4 and 65.6 ± 5.1 MSCs ICI 1 month and 3 months 50–60 ×10 6 IIEF-5, CDDU, FBS, HbA1c, morning erections No serious adverse events were reported. Al Demour et al [ 90 ] (2021) 22 DMED 59.18 ± 8.45 Wharton’s jelly-derived mesenchymal stem cells ICI Immediately, 24 h, and 1, 3, 6, and 12 months 20 × 10 6 IIEF-5, EHS, CDDU No serious adverse events were reported. Koga et al [ 91 ] (2022) 38 CNIED and DMED 56 Dental pulp stem cells ICI – 1 × 10 7 IIEF-5 No serious adverse events were reported.…”

Section: Stem Cell Applications In Human Clinical Trialsmentioning

confidence: 99%

Research Advances in Stem Cell Therapy for Erectile Dysfunction

Wang,

Liu,

Zhu

et al. 2024

BioDrugs

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Erectile dysfunction (ED) is a common clinical condition that mainly affects men aged over 40 years. Various causes contribute to the progression of ED, including pelvic nerve injury, diabetes, metabolic syndrome, age, Peyronie’s disease, smoking, and psychological disorders. Current treatments for ED are limited to symptom relief and do not address the root cause. Stem cells, with their powerful ability to proliferate and differentiate, are a promising approach for the treatment of male ED and are gradually gaining widespread attention. Current uses for treating ED have been studied primarily in experimental animals, with most studies observing improvements in erectile quality as well as improvements in erectile tissue. However, research on stem cell therapy for human ED is still limited. This article summarizes the recent literature on basic stem cell research on ED, including cavernous nerve injury, aging, diabetes, and sclerosing penile disease, and describes mechanisms of action and therapeutic effects of various stem cell therapies in experimental animals. Stem cells are also believed to interact with host tissue in a paracrine manner, and improved function can be supported through both implantation and paracrine factors. To date, stem cells have shown some preliminary promising results in animal and human models of ED. Supplementary Information The online version contains supplementary material available at 10.1007/s40259-024-00650-9.

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Safety and Efficacy of 2 Intracavernous Injections of Allogeneic Wharton’s Jelly-Derived Mesenchymal Stem Cells in Diabetic Patients with Erectile Dysfunction: Phase 1/2 Clinical Trial

Cited by 19 publications

References 28 publications

Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment

Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment

Vascular endothelium is the basic way for stem cells to treat erectile dysfunction: a bibliometric study

Research Advances in Stem Cell Therapy for Erectile Dysfunction

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