Safety and efficacy analysis by histology of weekly nab-paclitaxel in combination with carboplatin as first-line therapy in patients with advanced non-small-cell lung cancer

Abstract

First-line nab-P/C demonstrated a favorable risk-benefit profile in patients with NSCLC regardless of histology.

First line treatment of advanced non-small-cell lung cancer – specific focus on albumin bound paclitaxel

“…In patients with squamous histology, significantly increased ORR was seen in the nab-paclitaxel versus sbpaclitaxel arm (41% versus 24%, respectively; P,0.001). 70,71 The superior ORR reported here is one of the highest ever reported ORR in squamous NSCLC. The reason for improved response rate of nab-paclitaxel in squamous NSCLC remains unclear.…”

Chemoresistance factors in non-small cell lung cancer

“…В исследовании М. А. Socinski и соавт. (2013) при лечении NAB-паклитакселом на поздних стадиях НМКРЛ объективный ответ составил 33%, что статистически достоверно выше, чем в контрольной группе, объективный ответ в которой составил 17% (р<0,001) [28].…”

Nab-Paclitaxel and Carboplatin (Nab-PC) Regimen for Advanced Non-Small-Cell Lung Cancer

“…The studies reviewed reported nausea in 24% to 68% 1-3 of patients, grade 3 to 4 nausea in less than 1% to 11% [1][2][3]5,6 of patients, and vomiting in 33% of patients. 1 Appropriate acute emesis prophylaxis includes a serotonin antagonist and a corticosteroid plus or minus a neurokinin antagonist in selected patients.…”

“…Constitutional: Fatigue (all grades) 33% to 74%, [1][2][3] (grade 3 or 4) 3% to 6%. 2,3,5,6 B. Dermatologic: Alopecia (all grades) 49% to 100%, [1][2][3] (grade 3 or 4) 1% 3,6 …”

“…Gastrointestinal: Anorexia (all grades) 16% to 69%, [1][2][3] (grade 3 or 4) 1% to 17% [1][2][3]5,6 ; constipation (all grades) 54%, 2 (grade 3 or 4) 1% 2 ; nausea (all grades) 24% to 68%, [1][2][3] (grade 3 or 4) 1% to 11% [1][2][3]5,6 ; vomiting (all grades) 33%. 1 D. Hematologic: Anemia (all grades) 86% to 98%, [1][2][3] (grade 3 or 4) 16% to 32% 1,[3][4][5][6] ; febrile neutropenia (all grades) 3% to 11%, 1,3 (grade 3 or 4) less than 1% to 11% 1,3,5,6 ; leukopenia (all grades) 89% to 93%, 1,2 (grade 3 or 4) 24% to 50% 1,2,4 ; neutropenia (all grades) 83% to 94%, [1][2][3] (grade 3 or 4) 45% to 69% [1][2][3][4][5][6] ; thrombocytopenia (all grades) 61% to 81%, [1][2][3] (grade 3 or 4) 14% to 23%. [2]…”