Safety and Early Oncologic Outcomes of Lung Resection in Patients with Isolated Pulmonary Recurrent Prostate Cancer: A Single-center Experience

Ciriaco, Paola; Briganti, Alberto; Bernabei, Annalisa; Gandaglia, Giorgio; Carretta, Angelo; Viola, Cristina; Montorsi, Francesco; Negri, Giampiero

doi:10.1016/j.eururo.2018.12.029

Cited by 11 publications

(10 citation statements)

References 10 publications

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“…The role of pulmonary metastases resection is still unclear, with few literature results (16,17). A case series by Ciriaco et al (18) revealed that 1 of 20 patients with oligometastatic PCa, who underwent pulmonary resection, required hormone therapy. The median follow-up period was 23 months and PSA levels were not measurable during the follow-up.…”

Section: Discussionmentioning

confidence: 99%

Isolated Pulmonary Metastasis Metastasectomy After Curative Prostate Cancer Treatment in Oligometastatic Disease

Gemalmaz¹,

Abdullah²,

Dündar³

et al. 2021

uob

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Isolated pulmonary metastasis is observed in 2%-3% of prostate cancer cases but a complete treatment algorithm was not established for these patients. This study aimed to present a case of isolated pulmonary metastasis during the follow-up after radical prostatectomy, in which recurrence was not detected for 2 years after metastasectomy. The patient was on follow-up without any treatment for 22 months, with an unobservable prostate-specific antigen value. Metastasectomy in oligometastatic disease has emerged as a treatment option in recent years but is not considered a standard treatment. Literature contribution is necessary for oligometastatic disease definition to clarify its nature and compare treatment options.

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Section: Discussionmentioning

confidence: 99%

Isolated Pulmonary Metastasis Metastasectomy After Curative Prostate Cancer Treatment in Oligometastatic Disease

Gemalmaz¹,

Abdullah²,

Dündar³

et al. 2021

uob

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“…Ciriaco et al (2019) described 9 cases that underwent resection of lung metastases without preoperative ADT. [8] There are no reports describing the time-course of progression of isolated lung metastases from HSPC to CRPC in PrCa that remained confined to the lungs for over a decade.…”

Section: Discussionmentioning

confidence: 99%

“…[9] Early detection with improved imaging techniques opens avenues for local management of such lesions with surgery or radiotherapy. [8] Accrual of such patients to clinical trials and biospecimen collection is crucial in achieving a better understanding and improved management of this disease. The reported case illustrates the validity of utilization of ADT and modern anti-androgen therapy as well as the on-going investigation of stereotactic body radiotherapy in oligometastatic PrCa.…”

Section: Discussionmentioning

confidence: 99%

Radiographic and metabolic evolution of prostate cancer lung metastasis detected by prostate-specific membrane antigen and fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography

et al. 2020

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We describe the case of a 75-year-old patient who progressed over a 12-year period from localized to symptomatic metastatic prostate cancer (PrCa) with lung as the sole organ of involvement. In this case, the specific sequence of positron emission tomography (PET)-based next-generation imaging with 18 F-sodium fluoride-, 18 F-fluoro-2-deoxy-D-glucose-, and 18 F-DCFPyL PET/computed tomography and biopsies allowed illustration of the pathway of disease progression from nonglycolytic hormone-sensitive PrCa to glycolytic castrate-resistant PrCa without neuroendocrine features. The observations provide a unique insight into the timelines of anatomical and metabolic progression of metastatic PrCa. They highlight the value of close radiographic surveillance of metastatic PrCa with modern imaging to guide early treatment interventions.

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“…PCa cells in lung metastasis often retain the glandular features seen in the primary tumor, aiding in their identification. The majority of lung metastasis in prostate cancer arise from prostate adenocarcinoma, given its status as the most prevalent histological subtype of PCa [14,15,49,50]. Nevertheless, less common histological subtypes, such as small cell carcinoma and neuroendocrine carcinoma of the prostate, have been documented [51][52][53][54].…”

Section: Histopathologymentioning

confidence: 99%

Prostate Cancer Lung Metastasis: Clinical Insights and Therapeutic Strategies

Mahmoud,

Moustafa,

Day

et al. 2024

Preprint

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Prostate cancer lung metastasis represents a clinical conundrum due to their implication of advanced disease progression and the complexities they introduce in treatment planning. As the disease progresses to distant sites such as the lung, the clinical management becomes increasingly intricate, requiring tailored therapeutic strategies to address the unique characteristics of metastatic lesions. This review seeks to synthesize the current state of knowledge surrounding prostate cancer metastasis to the lung, shedding light on the diverse array of clinical presentations encountered, ranging from subtle radiological findings to overt symptomatic manifestations. By examining the diagnostic modalities utilized in identifying this metastasis, including advanced imaging techniques and histopathological analyses, the review aims to provide insights into the diagnostic landscape and the challenges associated with accurately characterizing lung metastatic lesions in prostate cancer patients. Moreover, the review delves into the nuances of therapeutic interventions employed in managing prostate cancer lung metastasis, encompassing systemic treatments such as hormonal therapies and chemotherapy, as well as metastasis-directed therapies including surgery and radiotherapy.

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Safety and Early Oncologic Outcomes of Lung Resection in Patients with Isolated Pulmonary Recurrent Prostate Cancer: A Single-center Experience

Cited by 11 publications

References 10 publications

Isolated Pulmonary Metastasis Metastasectomy After Curative Prostate Cancer Treatment in Oligometastatic Disease

Isolated Pulmonary Metastasis Metastasectomy After Curative Prostate Cancer Treatment in Oligometastatic Disease

Radiographic and metabolic evolution of prostate cancer lung metastasis detected by prostate-specific membrane antigen and fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography

Prostate Cancer Lung Metastasis: Clinical Insights and Therapeutic Strategies

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