“…Data from nonrandomized studies found that the highest median rate of withdrawals from adverse events was associated with INH-6 (median 5.8%, range 2.3%-24.5%; 9 studies 45,51,52,56,58,66,70,72,79 ), followed by INH/RPT-3 (median 4.3%, range 1.3%-8.4%; 7 studies 36,37,43,83,84,86,88 ), INH-9 (median 2.6%, range 0.4%-26.8%; 13 studies [41][42][43]48,49,54,57,62,65,67,77,86,88 ), INH/RMP 3-4 (median 1.8%, range 0.5%-5.1%; 4 studies 45,54,56,81 ), and RMP 3-4 (median 0%, range 0%-5.2%; 6 studies 36,45,48,49,57,58 ). 6 Severe reactions were those of grade 4 severity or associated with hypotension, anaphylaxis, loss of consciousness, or hospitalization.…”