Safety and Clinical Effectiveness of Percutaneous Vertebroplasty in the Elderly (≥80 years)

Clarençon, Frédéric; Fahed, Robert; Gabrieli, Joseph; Guermazi, Y.; Cormier, E.; Molet-Benhamou, Luc; Dadoun, Sabrina; Rose, M.; Jean, Lise Le; Chiras, J.

doi:10.1007/s00330-015-4035-2

Cited by 25 publications

(14 citation statements)

References 29 publications

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“…In contrast, Macias-Hernandez et al concluded that percutaneous VP had no advantages over conservative treatment for pain and function in a group of women ≥ 60 years of age with osteoporosis (21). Moreover, Clarençonet et al recently suggested that VP remains a safe and effective technique for pain relief, independent of the underlying disease in patients ≥ 80 years of age (22).…”

Section: Discussionmentioning

confidence: 99%

HER2-Positive Breast Cancer: Tumor-to-Liver SUV Ratio is the Best Parameter for Detection in F-18 FDG-PET/CT

et al. 2017

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Section: Discussionmentioning

confidence: 99%

HER2-Positive Breast Cancer: Tumor-to-Liver SUV Ratio is the Best Parameter for Detection in F-18 FDG-PET/CT

et al. 2017

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“…Percutaneous kyphoplasty (PKP) is an effective and currently widely used method for the treatment of osteoporotic vertebral compression fracture (OVCF), the procedure was done usually under local anesthesia, and the patient was well tolerated [1]. Early studies have shown that patients could obtain promising clinical outcome of immediate pain relief and functional improvement, especially among the elderly [2][3][4][5][6]. However, there is still a very number of patients who were unsatisfied with the result after operation.…”

Section: Introductionmentioning

confidence: 99%

Percutaneous kyphoplasty assisted with/without mixed reality technology in treatment of OVCF with IVC: a prospective study

Wei

Yao

et al. 2019

J Orthop Surg Res

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Background The purpose of this study was to assess the clinical outcome of percutaneous kyphoplasty (PKP) assisted with mixed reality (MR) technology in treatment of osteoporotic vertebral compression fracture (OVCF) with intravertebral vacuum cleft (IVC). Method Forty cases of OVCF with IVC undergoing PKP were randomized into a MR technology-assisted group (group A) and a traditional C-arm fluoroscopy group (group B). Both groups were performed PKP and evaluated by VAS scores, ODI scores, radiological evidence of vertebral body height, and kyphotic angle (KA) at pre-operation and post-operation. The volume of injected cement, fluoroscopy times, and operation time were recorded. And cases of non-PMMA-endplates-contact(NPEC) in radiological evidence was also recorded postoperatively. The clinical outcomes and complications were evaluated afterwards. All patients received 10 to 14 months follow-up, with an average of 12 months. Result This MR-assisted group (group A) acquired more about the amount of the polymethyl methacrylate (PMMA) injection and postoperative vertebral height and less about postoperative KA, fluoroscopy times, and operation time compared with the control group (group B) ( P < 0.05). The VAS scores and ODI scores in both groups have improved, but more significantly in group A ( P < 0.05). Also, more cases achieve both-endplates-touching of cement in group A ( P < 0.05). And there are less of the loss of vertebral height, KA, and occurrence of re-collapse of the vertebra in group A during the follow-up ( P < 0.05). Conclusion PKP assisted with MR technology can accurately orientate the position of IVC area, which can be augmented by the balloon leading to more satisfied vertebral height improvement, cement diffusion, and pain relief. Trial registration ClinicalTrials.gov Identifier: NCT03959059 . Registered 25 September 2016.

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“…Clarençon retrospectively analyzed the safety and clinical efficacy of PVP in 173 patients aged >80 years who had OVCFs. They found that 79.3% of the elderly patients attained pain relief after PVP and thus concluded that PVP is a safe treatment option for elderly patients [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Preoperative Zoledronic Acid Administration on Pain Intensity after Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures

Wang

Shi

et al. 2020

Pain Research and Management

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Introduction. This study aimed to compare and analyze the effect of preoperative zoledronic acid (ZOL) administration on pain intensity after percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fracture (OVCF). Methods. The study included 242 patients with OVCFs who underwent PVP in our hospital between January 2015 and June 2018. The patients were randomly assigned to either a ZOL group (n = 121) or a control group (n = 121). The patients in the ZOL group were treated preoperatively with intravenous infusion of 5 mg ZOL. Those in the control group were treated without ZOL. All the patients were followed up for 1 year. Results. No statistically significant differences in age, sex, weight, and body mass index (BMI) were found between the two groups. During the follow-up period, the visual analog scale score and Oswestry dysfunction index score in the ZOL group were lower than those in the control group. The bone mineral density at 6 or 12 months after treatment was significantly higher and the levels of the bone metabolism markers were significantly lower in the ZOL group than in the control group (P<0.05 for both). Two patients in the treatment group had new vertebral fractures, whereas 13 patients in the control group had new vertebral fractures, which translate to recompression vertebral fracture incidence rates of 1.7% and 10.7%, respectively. The incidence rate of mild adverse reactions was significantly higher in the ZOL group than in the control group, but all the cases were endurable. Conclusion. Intravenous infusion of ZOL before PVP can effectively reduce postoperative pain intensity, reduce bone loss, increase bone density, reduce the risk of refracture, and improve patient quality of life.

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Safety and Clinical Effectiveness of Percutaneous Vertebroplasty in the Elderly (≥80 years)

Abstract: • Post-PVP pain improvement was observed in 79.3 % of elderly patients. • PVP remains a safe technique in elderly patients. • No decompensation of comorbidity was observed in our series.

Cited by 25 publications

References 29 publications

HER2-Positive Breast Cancer: Tumor-to-Liver SUV Ratio is the Best Parameter for Detection in F-18 FDG-PET/CT

HER2-Positive Breast Cancer: Tumor-to-Liver SUV Ratio is the Best Parameter for Detection in F-18 FDG-PET/CT

Percutaneous kyphoplasty assisted with/without mixed reality technology in treatment of OVCF with IVC: a prospective study

Effect of Preoperative Zoledronic Acid Administration on Pain Intensity after Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures

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