Safer plant-based nanoparticles for combating antibiotic resistance in bacteria: A comprehensive review on its potential applications, recent advances, and future perspective

Anand, Uttpal; Carpena, María; Kowalska‐Góralska, Monika; García-Pérez, Pascual; Kumari, Sunita; Bontempi, Elza; Dey, Abhijit; Prieto, Miguel A.; Proćków, Jarosław; Simal-Gándara, Jesús

doi:10.1016/j.scitotenv.2022.153472

Cited by 65 publications

(34 citation statements)

References 244 publications

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“…Although ethanol is the predominant ingredient in most hand hygiene products, some gels also incorporate other synthetic substances that may not offer much in terms of protection but instead may fuel bacterial antimicrobial resistance (45). This may result in the selective survival of bacteria harboring resistance genes, and in the development of AMR (46)(47)(48). During the COVID-19 crisis, the massive use of these substances, in particular in hospitals, and the continued use of these hand hygiene products can lead to unintended release of biocides and disinfectants into wastewater and sewage treatment plants (49,50).…”

Section: Impact Of Covid-19 On the Release Of Antimicrobials Into The...mentioning

confidence: 99%

Antimicrobial Resistance in the COVID-19 Landscape: Is There an Opportunity for Anti-Infective Antibodies and Antimicrobial Peptides?

et al. 2022

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Although COVID-19 has captured most of the public health attention, antimicrobial resistance (AMR) has not disappeared. To prevent the escape of resistant microorganisms in animals or environmental reservoirs a “one health approach” is desirable. In this context of COVID-19, AMR has probably been affected by the inappropriate or over-use of antibiotics. The increased use of antimicrobials and biocides for disinfection may have enhanced the prevalence of AMR. Antibiotics have been used empirically in patients with COVID-19 to avoid or prevent bacterial coinfection or superinfections. On the other hand, the measures to prevent the transmission of COVID-19 could have reduced the risk of the emergence of multidrug-resistant microorganisms. Since we do not currently have a sterilizing vaccine against SARS-CoV-2, the virus may still multiply in the organism and new mutations may occur. As a consequence, there is a risk of the appearance of new variants. Nature-derived anti-infective agents, such as antibodies and antimicrobial peptides (AMPs), are very promising in the fight against infectious diseases, because they are less likely to develop resistance, even though further investigation is still required.

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Section: Impact Of Covid-19 On the Release Of Antimicrobials Into The...mentioning

confidence: 99%

Antimicrobial Resistance in the COVID-19 Landscape: Is There an Opportunity for Anti-Infective Antibodies and Antimicrobial Peptides?

et al. 2022

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“… 246 , 247 , 248 Ethno‐medico‐botanicals have been used across almost all the cultures worldwide against an array of human medical conditions. 50 , 51 , 52 , 53 The use of betel leaf alone and with a combination of other plants or medicines for better therapeutic effects is mentioned in the Ayurvedic literature, which was almost 1400 BC ago. 54 Atharved, the ancient Vedic literature, mentioned the usefulness of the betel plant against numerous diseases at about 3000–2500 BC before.…”

Section: Traditional and Ethno‐medicinal Usementioning

confidence: 99%

“…Scientists have developed green chemistry methods with the synthesis of nanomaterials using different biological sources which are more sustainable, cleaner and eco‐friendly, non‐toxic, energy‐efficient, that eliminates the need for high energy, pressure, temperature, and needs no stabilizing, reducing and capping agents from outside. 50 , 51 , 224 . The petiole extract of P. betle leaf was used to synthesize stable silver nanoparticles with or without CTAB (cetyltrimethylammonium bromide) and SDS (sodium dodecyl sulphate).…”

Section: Nanoformulationsmentioning

confidence: 99%

Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Biswas

Anand

Saha

et al. 2022

J Cellular Molecular Medi

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Piper betle L. (synonym: Piper betel Blanco), or betel vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as the green gold. The plant can be found all over the world and is cultivatedprimarily in South East Asian countries for its beautiful glossy heart‐shaped leaves, which are chewed or consumed as betelquidand widely used in Chinese and Indian folk medicine, as carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also used for religious purposes. Hydroxychavicol is the most important bioactive compound among the wide range of phytoconstituents found in essential oil and extracts. The pharmacological attributes of P . betle are antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal and many more. Immense attention has been paid to nanoformulations and their applications. The application of P . betle did not show cytotoxicity in preclinical experiments, suggesting that it could serve as a promising therapeutic candidate for different diseases. The present review comprehensively summarizes the botanical description, geographical distribution, economic value and cultivation, ethnobotanical uses, preclinical pharmacological properties with insights of toxicological, clinical efficacy, and safety of P . betle . The findings suggest that P . betle represents an orally active and safe natural agent that exhibits great therapeutic potential for managing various human medical conditions. However, further research is needed to elucidate its underlying molecular mechanisms of action, clinical aspects, structure–activity relationships, bioavailability and synergistic interactions with other drugs.

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“…NHCs with minimum one NH functional group within the carbene heterocyclic structure are called protic NHCs or pNHCs [7]. These NHCs are not stable, in the free form because of rapid tautomerization to the suitable azole [8].…”

Section: Structurementioning

confidence: 99%

Synthesis of Pincer type carbene and their Ag(I)-NHC complexes, and their Antimicrobial activities

Türkyılmaz

Ateş

2022

Journal of Sustainable Construction Materials and Technologies

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In this study, theophylline (1) compounds were synthesized with addition of 2-bromoetha-nol, 2-bromoacetamide and methyl-2-bromoacetate to attain symmetric connections to NHCs (2a–c). New complexes containing the symmetric N-heterocyclic carbene (NHC) ligands were synthesized using azolium salts in dimethyl formamide (DMF). After the NHC predecessor compounds reacted with Ag2O, Ag(I)-NHC complexes were synthesized in the following: 7,9-di-(2-hydroxyethyl)-8,9-dihydro-1,3-dimethyl-1H-purine-2,6(3H,7H)-dionedium silver(I)bromide (3a), 7,9-di(acetamide)-8,9-dihydro-1,3-dimethyl-1H-purine-2,6(3H,7H)-di-ondium silver(I)bromide (3b) and 7,9-di(methylacetate)-8,9-dihydro-1,3-dimethyl-1H-pu-rine-2,6(3H,7H)-diondiumsilver(I)bromide (3c). Both synthesized NHC predecessors (2a-c) and Ag(I)-NHC complexes (3a-c) were described by FTIR, 1H-NMR, 13C-NMR, liquid and solid-state conductivity values, TGA analysis, melting point analysis and XRD spectroscopy. In-vitro antibacterial activities of NHC-predecessors and Ag(I)-NHC complexes were tested against gram-positive bacteria (Staphylococcus Aureus and Bacillus Cereus), gram-negative bacteria (Escherichia Coli and Listeria Monocytogenes), and fungus (Candida Albicans) in Tryptic Soy Broth method. Ag(I)-NHC complexes showed higher antibacterial activity than pure NHC predecessors. The lowest microbial inhibition concentration (MIC) value of compound 3a was obtained as 11.56 μg/ml for Escherichia Coli and 11.52 μg/ml for Staphylococcus Aureus. All tested complexes displayed antimicrobial activity with different results.

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Safer plant-based nanoparticles for combating antibiotic resistance in bacteria: A comprehensive review on its potential applications, recent advances, and future perspective

Cited by 65 publications

References 244 publications

Antimicrobial Resistance in the COVID-19 Landscape: Is There an Opportunity for Anti-Infective Antibodies and Antimicrobial Peptides?

Antimicrobial Resistance in the COVID-19 Landscape: Is There an Opportunity for Anti-Infective Antibodies and Antimicrobial Peptides?

Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Synthesis of Pincer type carbene and their Ag(I)-NHC complexes, and their Antimicrobial activities

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