Abstract:Next-generation sequencing (NGS) has been widely used for calling biological variants. The gold-standard methodology for accessing the ability of a computational method to call a specific variant is to perform NGS wet-lab experiments on samples known to harbor this variant. Nevertheless, wet-lab experiments are both labor-intensive and time-consuming, and rare variants may not be present in a sample of population. Moreover, these two issues are exacerbated in SafeSeqS which enabled liquid biopsy and minimum-re… Show more
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