Safely effective hypoglycemic action of stevia and turmeric extracts on diabetic Albino rats

Abstract

The potentiality of Stevia leaves and turmeric roots as remedies against diabetes mellitus type 2 was tested in this study. Stevia leaves and turmeric roots were extracted with ethanol:water (80:20 v/v) and analyzed by HPLC. Turmeric extract (TUE) was rich in; curcumin, gallic acid, and eugenol. Stevia extract (STE) contained 28 known compounds, including glycosides, aromatic organic acids, and catechin. Fifty rats were divided into five groups (10 rats each); the control group were fed with feed and water ad libitum. Forty rats were injected a single dose of alloxan, then treated with either 10 mg/kg glibenclamide (GLI), 300 mg/kg STE, or 200 mg/kg TUE or water (positive control) through daily gastric oral gavages for 56 days. Treating diabetic rats with TUE significantly reduced serum glucose and glycated hemoglobin down to the negative control levels. Both GLI and STE produced similar but less effective actions. Animals treated with either STE or TUE exhibited reduced levels of liver and kidney markers compared to the negative control, while GLI increased them significantly. It could be concluded that turmeric roots and stevia leaves extracts can be used treatment for type 2 diabetes. Practical applications Turmeric roots and stevia leaves extracts may be used as a remedy for type 2 diabetic patients as aiding substituting treatments under medical supervision. The two plant sources can be used as raw materials for the extracts, which can be used under medical supervision as a gradual replacement of the synthetic antidiabetic drugs. These extracts can be used after a preliminary clinical study to determine the dose and frequency of administration. Stevia extract can be incorporated in drinks as a sweetener and drug. Turmeric extract has a bitter taste, so it may be incorporated in some foods such as bread, which is a traditional practice in some kinds of bread in Egypt.

Antihyperglycemic effect of turmeric aqueous root extract and morphological changes in the pancreas of alloxan-induced hyperglycemic Wistar rats

“…Tumeric extract was not only reported to reduce blood glucose levels but reduced glycated haemoglobin down to the negative control levels 16, 17 . The authors opined that the plant should be used as a dietary supplement for the management of diabetes mellitus and protection of the liver and kidney against the complications of the disease.…”

The ameliorative effect of turmeric (Curcuma longa Linn) extract and its major constituent, curcumin, and its analogs on ethanol toxicity

“…Turmeric is used in traditional medicine to treat liver and respiratory disorders, allergies, sinusitis, and anorexia (Razavi et al, 2021). At present, this herb is also known to have antirheumatic (Nakisa & Rahbardar, 2021), anti‐cancer (Gurer et al, 2022), antidotal (Ara et al, 2020; Hosseini & Hosseinzadeh, 2018), anti‐hypertriglyceridemia (Mollazadeh et al, 2019), hypoglycemic (El‐Hadary & Sitohy, 2021), anti‐depressive (Alavi et al, 2021), hepatoprotective, anti‐obesity (Vafaeipour et al, 2022), cardioprotective (Akhter & Nahar, 2022), and anti‐microbial (Soleimani et al, 2018) effects. Additionally, turmeric has been shown to have anti‐inflammatory (Liu et al, 2022), antioxidant (Adab et al, 2019), and anti‐apoptotic (Ibrahim et al, 2019) effects in numerous studies.…”

Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

“…(22). Over the few current decades, considerable studies have been conducted on curcumin due to its beneficial health properties, including potent antioxidant properties (23,24), antimicrobial (25), antiinflammation (26), anticancer effects (27), cardio-protectiveness (28), and hypoglycemic action (29).…”