Safe, Effective Chin and Jaw Restoration With VYC-25L Hyaluronic Acid Injectable Gel

Ogilvie, Patricia; Sattler, Gerhard; Gaymans, Frodo; Belhaouari, Lakhdar; Weichman, Barry M.; Snow, Sean; Chawla, Smita; Abrams, Steve; Schumacher, Andrew

doi:10.1097/dss.0000000000001960

Cited by 42 publications

(63 citation statements)

References 19 publications

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“…Four subjects experienced speech disorder (specifically, unclear pronunciation) following initial and touch-up treatments, and 1 subject experienced unclear pronunciation following repeat treatment. 8 …”

Section: Resultsmentioning

confidence: 99%

“…The design of the study has been previously reported. 8 Briefly, subjects were randomly assigned in a 3:1 ratio to treatment with Volux at the beginning of the study (Volux group) or after a 3-month delay (control group). During the 3-month delay, control subjects underwent 3-dimensional facial imaging at month 1 and month 3; after receiving initial treatment at month 3, the controls and the Volux treatment group underwent the same procedures.…”

Section: Methodsmentioning

confidence: 99%

“…Subject eligibility has been previously described. 8 Briefly, subjects (18 years of age or older) had to have chin retrusion (glabella-subnasale-pogonion angle 145°-165°) that was amenable to correction with increased horizontal projection. Subjects could not have: received permanent facial implants in the face or neck; undergone semipermanent soft tissue filler treatment in the chin or jaw within 36 months before enrollment; undergone soft tissue filler injections, fat injections, or surgery in the chin or jaw within 24 months before enrollment; undergone any dental procedure (other than prophylaxis or fillings) during the study; received soft tissue filler injection in the glabellar area or nose within 12 months before enrollment; or undergone mesotherapy or cosmetic resurfacing in the face or neck, or botulinum toxin injections below the subnasale within 6 months before enrollment.…”

Section: Methodsmentioning

confidence: 99%

“…The primary effectiveness endpoint was the comparison of mean change from baseline in glabella-subnasale-pogonion angle between the Volux group and the control group at month 3, which has been previously reported. 8 Glabella-subnasale-pogonion angle was assessed via 3D facial digital imaging.…”

Section: Methodsmentioning

confidence: 99%

“…The study met the 3-month primary effectiveness endpoint, showing that the mean change in facial angle from baseline at month 3 was significantly greater in the treatment vs delayed treatment (control) group (difference: 2.51°; P < 0.0001), with treatment effects sustained for up to 12 months. 8 This report presents safety, effectiveness, and satisfaction results for Volux through 18 months after treatment and at 1 month after repeat treatment in subjects with chin retrusion.…”

mentioning

confidence: 98%

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VYC-25L Hyaluronic Acid Injectable Gel Is Safe and Effective for Long-Term Restoration and Creation of Volume of the Lower Face

Ogilvie¹,

Benouaiche²,

Philipp‐Dormston³

et al. 2020

Aesthetic Surgery Journal

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Background Juvéderm Volux (VYC-25L; Allergan plc) is an injectable hyaluronic acid gel designed to restore and create facial volume. Objective The aim of this study was to evaluate the safety and effectiveness of Volux for chin retrusion over 18 months and after repeat treatment. Methods This prospective, single-blind, controlled study enrolled subjects aged ≥18 years with chin retrusion (glabella-subnasale-pogonion facial angle 145°-165°). Subjects were randomized (3:1) to Volux at study onset or 3 months later (control group), and could receive a single repeat treatment during months 18 to 24. Assessments included mean facial-angle change from baseline, Global Aesthetic Improvement Scale (GAIS) responder rates (improved/much improved), improvements in 3 subject-reported FACE-Q scales, and safety. Results Of 132 enrolled subjects, 119 received initial Volux treatment and 89 received repeat treatment. Mean changes (95% confidence interval) in glabella-subnasale-pogonion angle from baseline for treatment and control groups, respectively, were: 1.15° (0.75°, 1.56°) and 1.16° (0.57°, 1.75°) at month 18, and 3.14° (2.68°, 3.61°) and 2.72° (1.78°, 3.66°) 1 month after repeat treatment. Investigators rated 52.5%/60.0% of treated/control subjects at month 18 and 96.9%/100% after retreatment as GAIS responders; subject-reported rates were 62.0%/64.0% and 93.8%/100%. Durable improvements in Satisfaction with Chin, Satisfaction with Lower Face and Jawline, and Psychological Well-Being were reported in 82.1%, 78.2%, and 60.3% of subjects, respectively, at month 18, and 92.3%, 93.8%, and 67.7% of subjects after retreatment. The safety profile was as expected. Conclusions Volux injectable gel is a safe, effective, and durable alternative to surgical treatments for increasing chin projection and jaw volume, and results in high patient satisfaction. Level of Evidence: 2

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 98%

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VYC-25L Hyaluronic Acid Injectable Gel Is Safe and Effective for Long-Term Restoration and Creation of Volume of the Lower Face

Ogilvie¹,

Benouaiche²,

Philipp‐Dormston³

et al. 2020

Aesthetic Surgery Journal

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Using injectable fillers for chin and jawline rejuvenation

Frost

Friedman

2023

World j. otorhinolaryngol.-head neck surg.

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Objective: As the population ages, facial plastic providers must remain aware of the treatments to prevent and reverse the external signs of aging. In the mandibular region, skin laxity and soft tissue sagging in the jawline may lead to jowling and chin ptosis along with reduced chin projection. While surgical procedures, including chin implantation, may be performed, nonsurgical procedures are becoming increasingly popular due to their temporary, noninvasive, yet effective methods. This review covers the use of hyaluronic acid, calcium hydroxylapatite, poly-L-lactic acid, and polymethyl methacrylate in the jawline.Methods: PubMed was searched for data on the mechanism of action, pertinent anatomy, indications, contraindications, technique, and evidence supporting the safety and efficacy of the fillers.Results: There are a wide variety of fillers available for use in the lower face with unique characteristics and application methods. While the advantages of injectable fillers include relatively affordable cost, minimal patient discomfort, and limited recovery times, taking measures to prevent short-and long-term complications is necessary for optimal results. Conclusions: Understanding the benefits and limitations of injectable fillers in the jawline can help providers appropriately counsel and treat patients.

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The Use of the FACE-Q Aesthetic: A Narrative Review

et al. 2022

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Introduction In the past decade there has been an increasing interest in the field of patient-reported outcome measures (PROMs) which are now commonly used alongside traditional outcome measures, such as morbidity and mortality. Since the FACE-Q Aesthetic development in 2010, it has been widely used in clinical practice and research, measuring the quality of life and patient satisfaction. It quantifies the impact and change across different aspects of cosmetic facial surgery and minimally invasive treatments. We review how researchers have utilized the FACE-Q Aesthetic module to date, and aim to understand better whether and how it has enhanced our understanding and practice of aesthetic facial procedures. Methods We performed a systematic search of the literature. Publications that used the FACE-Q Aesthetic module to evaluate patient outcomes were included. Publications about the development of PROMs or modifications of the FACE-Q Aesthetic, translation or validation studies of the FACE-Q Aesthetic scales, papers not published in English, reviews, comments/discussions, or letters to the editor were excluded. Results Our search produced 1189 different articles; 70 remained after applying in- and exclusion criteria. Significant findings and associations were further explored. The need for evidence-based patient-reported outcome caused a growing uptake of the FACE-Q Aesthetic in cosmetic surgery and dermatology an increasing amount of evidence concerning facelift surgery, botulinum toxin, rhinoplasty, soft tissue fillers, scar treatments, and experimental areas. Discussion The FACE-Q Aesthetic has been used to contribute substantial evidence about the outcome from the patient perspective in cosmetic facial surgery and minimally invasive treatments. The FACE-Q Aesthetic holds great potential to improve quality of care and may fundamentally change the way we measure success in plastic surgery and dermatology. Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Safe, Effective Chin and Jaw Restoration With VYC-25L Hyaluronic Acid Injectable Gel

Cited by 42 publications

References 19 publications

VYC-25L Hyaluronic Acid Injectable Gel Is Safe and Effective for Long-Term Restoration and Creation of Volume of the Lower Face

VYC-25L Hyaluronic Acid Injectable Gel Is Safe and Effective for Long-Term Restoration and Creation of Volume of the Lower Face

Using injectable fillers for chin and jawline rejuvenation

The Use of the FACE-Q Aesthetic: A Narrative Review

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