Sacroilitis in Preschool Children: A Case Series and Review of the Literature

Alcobendas, Rosa; Loza, Sara Murias; Camba, Agustín Remesal; Udaondo, Clara; Rey, Cristina Calvo

doi:10.1097/inf.0000000000002691

Cited by 8 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…22 However, an exclusively oral therapeutic management is yet under evaluation within the pediatric population. 9,[23][24][25] The precedent randomized controlled trials in adults comparing oral to IV therapy for bone infection concluded that oral antibiotic therapy is at least as effective as IV, showing higher adverse event rates and decreased patient satisfaction in the IV groups. 7,8 The Pediatric Rheumatology Unit from the Hospital La Paz, Madrid, started in 2008 a pilot study in which selected children with OAI probably caused by K. kingae who met certain criteria were treated exclusively with oral antibiotic therapy, even if the etiology was not yet determined.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 The Pediatric Rheumatology Unit from the Hospital La Paz, Madrid, started in 2008 a pilot study in which selected children with OAI probably caused by K. kingae who met certain criteria were treated exclusively with oral antibiotic therapy, even if the etiology was not yet determined. 9,[23][24][25] All patients treated entirely orally were managed by scheduled visits to the Pediatric Rheumatology Unit, where the staff provided daily consultation, discussed questions, examined the children and/or performed new arthrocentesis if necessary. After initiation of oral antibiotic therapy, patients are examined within 24-48 hours searching for clinical improvement (decrease in pain, increase in range of motion and disappearance of fever).…”

Section: Discussionmentioning

confidence: 99%

“…22 However, an exclusively oral therapeutic management is yet under evaluation within the pediatric population. 9,23–25…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Oral Versus Intravenous Antibiotics for Pediatric Osteoarticular Infection: When and to Whom?

Rueda

Núñez

Martin

et al. 2022

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

Background: Osteoarticular infections (OAIs) are typically treated initially with intravenous antibiotics. The objective of this study was to evaluate whether an exclusive oral treatment in selected children may be appropriate. Methods: The Spanish Network of Osteoarticular Infections is a nationwide multicenter registry comprising 37 hospitals in Spain. The registry prospectively includes clinical characteristics and outcome of children with OAI. One of the hospitals from RioPed offers oral treatment to children meeting certain criteria. Patients were classified into 2 groups. Group 1: management with initial intravenous antibiotic therapy. Group 2: patients exclusively treated with oral antibiotics. A comparison between the 2 groups was performed. Results: We compared 893 children who initially received intravenous antibiotics (group 1) with 64 children who received exclusively oral therapy (group 2). Patients from group 2 were younger (33.9 vs. 20.3 months; P = 0.001), had a lower percentage of Staphylococcus aureus (23.3% vs. 3.1%; P < 0.001), a higher proportion of Kingella kingae (12.1% vs. 28.1%; P = 0.001), higher erythrocyte sedimentation rate/C-reactive protein (CRP) ratio (1.4 interquartile range 0.6–3.6 vs. 3.3 interquartile range 1.7–5.7; P < 0.001) and showed lower rate of fever (63% vs. 48.8%; P = 0.024) than in group 1. Complications were not found in group 2. Conclusions: An exclusively oral administration could be a safe option in selected patients with OAI. Low-risk criteria are proposed: good general condition, no underlying disease, 6 months to 3 years old, appropriate oral tolerance, C-reactive protein <80 mg/L, erythrocyte sedimentation rate/C-reactive protein ratio ≥0.67, no skin injury, no recent surgery, no cervical spondylodiscitis and no local complications at onset.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oral Versus Intravenous Antibiotics for Pediatric Osteoarticular Infection: When and to Whom?

Rueda

Núñez

Martin

et al. 2022

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

show abstract

“…In a prospective study, Peltola et al observed that shorter courses of initial intravenous therapy (2-4 days) followed by oral therapy for 2-3 weeks could be a safe option in children with uncomplicated OAI, especially in children under 3 years in which K.kingae is the main germen identi ed (5,22). However, an exclusively oral therapeutic management is yet under evaluation within the pediatric population (8, [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…The Pediatric Rheumatology Unit from the Hospital La Paz, Madrid, started in 2008 a pilot study based on treating selected children with OAI probably caused by K. kingae who meet certain criteria for undergoing an exclusively oral antibiotic therapy, even if the etiology was not yet determined (8, [23][24][25]. All patients treated entirely orally were managed by scheduled visits to the Pediatric Rheumatology Unit, where the staff provided daily consultation, discussed questions, examined the children, and/or performed new arthrocentesis if necessary.…”

Section: Discussionmentioning

confidence: 99%

Oral Versus Intravenous Antibiotics for Pediatric Osteoarticular Infection: When and to Whom?

Alcobendas¹,

Núñez²,

Martin³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background Osteoarticular infections are typically treated initially with intravenous antibiotics. The objective of this study was to evaluate whether an exclusive oral treatment in selected children may be appropriate. Methods The Spanish Network of Osteoarticular Infections is a nationwide multicenter registry comprising 37 hospitals in Spain. The registry prospectively includes clinical characteristics and outcome of children with OAI. One of the hospitals from RioPed offers oral treatment to children meeting certain criteria. Patients were classified into two groups. Group 1: management with initial intravenous antibiotic therapy. Group 2: patients exclusively treated with oral antibiotics. A comparison between the two groups was performed. Results We compared 893 children who initially received intravenous antibiotics (Group 1) with 64 children who received exclusively oral therapy (Group 2). Patients from Group 2 were younger (33.9 vs 20.3 months; p=0.001), had a lower percentage of Staphylococcus aureus (23.3% vs 3.1%, p <0.001), a higher proportion of Kingella kingae (12.1% vs 28.1%; p = 0.001), higher ESR/CRP ratio (1.4 IQR 0.6-3.6 vs 3.3 IQR 1.7-5.7, p <0.001) and showed lower rate of fever (63% vs 48.8%; p=0.024). Complications were not found in Group 2. Conclusion An exclusively oral administration could be a safe option in selected patients with OAI. Low-risk criteria are proposed: good general condition, no underlying disease, 6 months-3 years of age, appropriate oral tolerance, CRP ≤80 mg/L, ESR/CRP ratio ≥ 0.67, no skin injury, no recent surgery, no cervical spondylodiscitis and no local complications at onset.

show abstract

Clinical Practice Guideline by the Pediatric Infectious Diseases Society (PIDS) and the Infectious Diseases Society of America (IDSA): 2023 Guideline on Diagnosis and Management of Acute Bacterial Arthritis in Pediatrics

Woods,

Bradley,

Chatterjee

et al. 2023

Journal of the Pediatric Infectious Diseases Society

View full text Add to dashboard Cite

This clinical practice guideline for the diagnosis and treatment of acute bacterial arthritis (ABA) in children was developed by a multidisciplinary panel representing the Pediatric Infectious Diseases Society (PIDS) and the Infectious Diseases Society of America (IDSA). This guideline is intended for use by healthcare professionals who care for children with ABA, including specialists in pediatric infectious diseases and orthopedics. The panel’s recommendations for the diagnosis and treatment of ABA are based upon evidence derived from topic-specific systematic literature reviews. Summarized below are the recommendations for the diagnosis and treatment of ABA in children. The panel followed a systematic process used in the development of other IDSA and PIDS clinical practice guidelines, which included a standardized methodology for rating the certainty of the evidence and strength of recommendation using the GRADE approach (Grading of Recommendations Assessment, Development and Evaluation) (see Figure 1). A detailed description of background, methods, evidence summary and rationale that support each recommendation, and knowledge gaps can be found online in the full text.

show abstract

Sacroilitis in Preschool Children: A Case Series and Review of the Literature

Cited by 8 publications

References 15 publications

Oral Versus Intravenous Antibiotics for Pediatric Osteoarticular Infection: When and to Whom?

Oral Versus Intravenous Antibiotics for Pediatric Osteoarticular Infection: When and to Whom?

Oral Versus Intravenous Antibiotics for Pediatric Osteoarticular Infection: When and to Whom?

Clinical Practice Guideline by the Pediatric Infectious Diseases Society (PIDS) and the Infectious Diseases Society of America (IDSA): 2023 Guideline on Diagnosis and Management of Acute Bacterial Arthritis in Pediatrics

Contact Info

Product

Resources

About