Sacroiliac joint pain as an important element of psoriatic arthritis diagnosis

Krawczyk-Wasielewska, Agnieszka; Skorupska, Elżbieta; Samborski, Włodzimierz

doi:10.5114/pdia.2013.34161

Cited by 8 publications

(7 citation statements)

References 43 publications

(58 reference statements)

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“…Sacroilitis is present in 34-78% of psoriatic patients 12 . The patient in this report presented with bleeding Psoriatic patches and dactylitis in addition to the lower back pain.…”

Section: Discussionmentioning

confidence: 99%

Methicillin Resistant Staphylococcus Aureus Sacroiliac Joint Septic Arthritis in an Adult Patient Treated with Daptomycin

Rashed

Younis

2017

J. Bone Joint Infect.

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Sacroiliac joint septic arthritis is a rare disease entity representing 1-2% of all cases of septic arthritis. Establishment of the diagnosis is often challenging given the non-specific presenting features and the potential cross-over with other pathologies. We report the case of a 50 year old gentleman who suffers with psoriasis and presented with sacroiliac joint septic arthritis complicated by Methicillin Resistant Staphylococcus Aureus (MRSA) bacteraemia and an iliopsoas abscess. This was successfully treated conservatively with a course of the novel antibiotic Daptomycin.

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“…Sacroilitis is present in 34-78% of psoriatic patients 12 . The patient in this report presented with bleeding Psoriatic patches and dactylitis in addition to the lower back pain.…”

Section: Discussionmentioning

confidence: 99%

Methicillin Resistant Staphylococcus Aureus Sacroiliac Joint Septic Arthritis in an Adult Patient Treated with Daptomycin

Rashed

Younis

2017

J. Bone Joint Infect.

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“…The significant joint pain, stiffness, and structural damage caused by spondyloarthropathies are well established, as are the serious associated functional impairment and reduction in HRQoL. 28–41…”

Section: Introductionmentioning

confidence: 99%

Treating to Target(s) With Interleukin-17 Inhibitors

et al. 2019

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Background: The treat-to-target (T2T) strategy has become established in several medical specialties as a key guidance to optimal therapeutic decision making. T2T may be effective in the assessment of the biologic class of agents called interleukin (IL)-17 inhibitors, which are emerging as a safe and effective treatment option for autoimmune inflammatory conditions such as plaque psoriasis, psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Objective: The objective of this article is to use a T2T approach for the evaluation of the effectiveness and safety of IL-17 inhibitors in the management of patients with plaque psoriasis, PsA, and AS. Methods: Following a comprehensive literature search, a full-day meeting was convened to discuss and identify the T2T targets for psoriasis, PsA, and AS. Clinical trial evidence was presented for the approved IL-17 inhibitors—secukinumab, ixekizumab, and brodalumab—to assess whether these data meet T2T safety and efficacy targets. Results: All 3 approved agents were significantly superior to placebo and active controls in the achievement of T2T targets for psoriasis. Secukinumab and ixekizumab were likewise associated with significantly better outcomes than controls in the PsA targets, and secukinumab resulted in significant AS target improvements vs placebo. The IL-17 inhibitors were also associated with low rates of serious adverse events and exacerbations of common comorbid conditions. Conclusion: Phase III trial results support the T2T benefit and safety of IL-17 inhibitors according to their specific indications for the management of patients with plaque psoriasis, PsA, and AS.

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“…This process results in a sausage-shaped swelling of the fingers and toes called dactylitis (9). PsA can also affect the hips, spine (spondylitis), knees, and sacroiliac joint (sacroiliitis), and any other joint (11). Dermatologic manifestations of PsO appear before the manifestations of arthritis in about 75% of patients (10).…”

Section: Introductionmentioning

confidence: 99%

Psoriasis, Psoriatic Arthritis, and Thyroid Autoimmunity

et al. 2017

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Psoriasis (PsO) is a chronic relapsing/remitting autoimmune skin disease, associated with an increased risk of other autoimmune disorders. Psoriatic arthritis (PsA) is a chronic inflammatory arthritis occurring approximately in 30% of PsO patients. Sporadic cases of association between PsO and autoimmune thyroid disorders (AITDs) have been reported. However, two different recent studies did not find any association between them. In patients with PsO and PsA, an association with AITD has been shown by most of the studies in adults, but not in the juvenile form. In PsA women and men, thyroid autoimmunity [positive antithyroid peroxidase (AbTPO) antibodies, hypoechoic thyroid pattern] and subclinical hypothyroidism were more prevalent than in the general population. An association has been shown also in patients with PsO, arthritis, and inflammatory bowel disease, who have more frequently AITD. A Th1 immune predominance has been shown in early PsO, and PsA, with high serum CXCL10 (Th1 prototype chemokine), overall in the presence of autoimmune thyroiditis. This Th1 immune predominance might be the immunopathogenetic base of the association of these disorders. A raised incidence of new cases of hypothyroidism, thyroid dysfunction, positive AbTPO, and appearance of a hypoechoic thyroid pattern in PsA patients, especially in women, has been shown recently, suggesting to evaluate AbTPO levels, thyroid function, and thyroid ultrasound, especially in PsA women. Thyroid function follow-up and suitable treatments should be performed regularly in PsA female patients at high risk (thyroid-stimulating hormone within the normal range but at the higher limit, positive AbTPO, hypoechoic, and small thyroid).

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Sacroiliac joint pain as an important element of psoriatic arthritis diagnosis

Cited by 8 publications

References 43 publications

Methicillin Resistant Staphylococcus Aureus Sacroiliac Joint Septic Arthritis in an Adult Patient Treated with Daptomycin

Methicillin Resistant Staphylococcus Aureus Sacroiliac Joint Septic Arthritis in an Adult Patient Treated with Daptomycin

Treating to Target(s) With Interleukin-17 Inhibitors

Psoriasis, Psoriatic Arthritis, and Thyroid Autoimmunity

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