Sacrococcygeal teratoma: Nationwide survey and guidelines

Taguchi, Tomoaki

doi:10.1111/ped.13933

Cited by 8 publications

(5 citation statements)

References 6 publications

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“…Recently published guidelines for follow-up surveillance of resected SCT with benign (mature or immature) histology emphasize the importance of physical examination, selective imaging and serum AFP monitoring until at least 3 years after initial treatment (11). Following GCT resection in any newborn or infant, AFP monitoring during infancy should be monthly to ensure that an early recurrence is not confused with a persistent physiologic AFP elevation.…”

Section: Post-resection Surveillance Of Sctmentioning

confidence: 99%

Case Reports: Management Challenges in Pediatric Germ Cell Tumors

2021

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Germ cell tumors in infants are most frequently extragonadal, benign, and amenable to surgical resection. An unusual feature of germ cell tumors is the potential coexistence of malignant with benign disease which makes it possible for patients with incompletely resected tumors to experience either a benign or malignant recurrence. A challenge to postoperative surveillance is the interpretation of serum alpha fetoprotein, a marker of malignancy, that is physiologically elevated during the first year of life. A rare subset of germ cell tumors occur in the retroperitoneum. Although the vast majority are benign, these tumors are often large and distort normal anatomy, and may demonstrate local invasiveness that increases risk of resection. The intent of these reports is to caution readers about these unusual features of germ cell tumors of infancy.

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Section: Post-resection Surveillance Of Sctmentioning

confidence: 99%

Case Reports: Management Challenges in Pediatric Germ Cell Tumors

2021

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“…Hemorrhagic complications are the most common cause of death during surgical resection in the neonatal period. 25 , 26 Disseminated intravascular coagulation developed in 1 of our cases after surgery. Another complication is injuries to the colon, ureter, and bladder during surgery, particularly in type 4 cases.…”

Section: Discussionmentioning

confidence: 76%

Clinicopathological Evaluation of Childhood Sacrococcygeal Germ Cell Tumors: A Single-Center Experience

Hasbay¹,

Canpolat²,

Aktekin³

et al. 2022

Turk Arch Pediatrics

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Objective We aimed to evaluate the cases of sacrococcygeal germ cell tumors diagnosed in our hospital between 2006 and June 2021. Materials and Methods We evaluated 38 sacrococcygeal germ cell tumors cases in our series in terms of age, sex, clinical complaints, localization, macroscopy, tumor size, histopathological diagnosis, surgical, postoperative complications, treatment, recurrence, and prognosis. Results The cases ranged from 1 day to 16 years of age; 14 cases were diagnosed with routine ultrasonographic examination during prenatal period while the rest of the cases most frequently presented with complaints of constipation. In terms of localization, 6 cases were type 1, 11 cases were type 2, 6 cases were type 3, and 15 cases were type 4. In the pathological evaluation, 25 cases were mature teratoma, 8 cases were immature teratoma, and 5 cases were pure yolk-sac tumor. In terms of complications, temporary colostomy was performed as a result of rupture during birth in 2 cases, disseminated intravascular coagulation at birth in 1 case, and colon injury in 2 cases. There was a recurrence in 2 of our cases. Thirty-seven of our cases were alive and 1 died. Alpha-fetoprotein level was high in 28 of our cases. Conclusion In our series, type 4 cases were observed more frequently, contrary to the literature. We recommend to use a routine ultrasonography to patients who come to the clinic with complaints of constipation and inability to urinate and if a mass is detected, asking for alpha-fetoprotein for further follow-up. Sacrococcygeal germ cell tumors are ultimately a disease that can be successfully treated with multidisciplinary approach, accurate diagnosis in the antenatal and postnatal period, appropriate surgical intervention, and regular follow-up.

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“…At prenatal diagnosis, the prognosis is poor, with frequent intrauterine death, mainly due to cardiac failure. In contrast, the prognosis is excellent after surgical intervention for postnatally diagnosed sacrococcygeal teratomas [54].…”

Section: Fetal Morphology and Prognosismentioning

confidence: 98%

“…The origin of the cells is remnant cells of the primitive streak or primordial germ cells [53]. It is more common in female foetuses, with a 4:1 ratio [54].…”

Section: Epidemiologymentioning

confidence: 99%