Sacrococcygeal immature teratoma with malignant ependymoma component

Busse, Claudia; Kanwar, Vikramjit S.; Wolden, Suzanne L.; LaQuaglia, Michael P.; Rosenblum, Marc K.

doi:10.1002/pbc.22079

Cited by 12 publications

(8 citation statements)

References 7 publications

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“…Morphologically, they resemble the myxopapillary-type CNS ependymomas (37–42). Immunohistochemically also they resemble CNS ependymomas more than other extraneural ependymomas do (3,40). Presacral ependymomas are frequently associated with destruction of sacral bone or dysfunction of sacral nerve.…”

Section: Discussionmentioning

confidence: 86%

“…Sacrococcygeal ependymomas are believed to arise from extradural filum terminale or from ependymal cell rests resulting from incomplete regression of the caudal cell mass (2,37–39). This belief is based on the fact that sacrococcygeal ependymomas are located in the vicinity of filum terminale and share the characteristic morphology of myxopapillary-type CNS ependymoma (3,37–40). Immunohistochemically also they resemble CNS ependymomas more than other extraneural ependymomas (3,40) and like CNS ependymomas, they are equally distributed among males and females (37–40).…”

Section: Discussionmentioning

confidence: 99%

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Pelvic Ependymoma With Clinical Response to GnRH Analog Therapy

Zhou

Song

Mikolaenko

et al. 2015

International Journal of Gynecological Pathology

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Summary Extraneural ependymomas are rare tumors that occur in sacrococcygeal, pelvic and extra pelvic regions. While sacrococcygeal extraneural ependymomas are equally distributed among males and females, pelvic and extra pelvic ependymomas have been exclusively reported in women, mainly of child bearing age. We present a case of extraneural, pelvic ependymoma that showed clinical response to GnRH therapy with its immunohistochemical and electron microscopic analysis, and an overview of primary extraneural ependymomas based on a review of all such cases published in English literature.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Pelvic Ependymoma With Clinical Response to GnRH Analog Therapy

Zhou

Song

Mikolaenko

et al. 2015

International Journal of Gynecological Pathology

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“…Singular case reports of sacrococcygeal teratoma with MPE[12] and anaplastic ependymoma[13] components are on record. Extensive sampling of our specimen did not reveal any germ cell or teratomatous component, which was further substantiated by normal serum AFP and β-HCG levels.…”

Section: Discussionmentioning

confidence: 99%

Sacrococcygeal myxopapillary ependymoma with anaplastic ependymoma component in an infant

et al. 2012

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Sacrococcygeal location of myxopapillary ependymoma (MPE) is uncommon. Local recurrence and metastases are on record inspite of its benign characteristics. We report a rare case of sacrococcygeal MPE in an 11-month-old female child who showed typical myxopapillary ependymal histology along with anaplastic ependymal component. Ki-67 labeling index in the myxopapillary component was 4-5% and in the anaplastic component was 70%. Six weeks after gross total resection of the tumor, the child presented with local recurrence and metastasis in the right inguinal lymph nodes and was treated with chemotherapy. The present case of sacrococcygeal MPE with anaplastic ependymoma component is the second case on record in the medical literature, and the first case without any syndromic features. Metastasis in this case can be explained because of the anaplastic component, with mitotic count of 5-6/high power field and high Ki-67 labeling index.

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“…Extraaxial ependymomas are also believed to derive from progenitor cells, and their occurrence in teratomas seems to support this view. 3,8,21 A progenitor cell hypothesis could therefore also be suggested to explain CEs, but whether such progenitor cells result from a migration defect of subependymal neural progenitors remains to be established.…”

Section: Discussionmentioning

confidence: 99%

Cortical ependymoma: an unusual epileptogenic lesion

Gompel¹,

Koeller

Meyer³

et al. 2011

JNS

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Object Supratentorial cortical ependymomas (CE) are rare, with 7 cases reported. The lesions, typically occurring in the superficial cortex in young adults and associated with a history of seizures, are not fully characterized. Furthermore, their relationship with the recently described angiocentric glioma (AG) is still being debated. This study was undertaken to summarize the authors’ experience with CEs. Methods Between 1997 and 2009, 202 cases of ependymoma were surgically treated at the Mayo Clinic, 49 of which were supratentorial. Among these, 9 CE cases were retrospectively identified. Clinical, imaging, and pathological features of each case were reviewed. Results Tumors arose from the frontal (5 cases), parietal (3), and occipital (1) lobes. No tumor occurred in the temporal lobe, despite its reported association with seizures. The mean age at presentation was 27 ± 19 years (± SD) and age at resection was 36 ± 16 years. The mean size of the lesion was 16 ± 14 cm3. Seizures were the presenting symptom in 78%. Cross-sectional imaging in 8 cases was characterized by a heterogeneous mass with multiple cystlike areas and enhancement of the soft-tissue component. Gross-total resection was achieved in 8 of 9 tumors. Pathologically, 6 were low-grade (WHO Grade II) and 3 were anaplastic (WHO Grade III) ependymomas. All tumors exhibited the focal presence of perivascular pseudorosettes, but only 1 (11 %) exhibited the focal presence of a true rosette. A bipolar spindle cell component resembling AG was present in 3 (33%) and “Schwannian-like” nodules in 2 (22%). Subpial aggregation and peripheral infiltration were present in 4 cases (44%}. With a mean postsurgery follow-up of 62 ± 38 months, only 2 lesions recurred locally after imaging-confirmed gross-total resection, both being Grade III. In 5 (71 %) of 7 patients presenting with seizures an Engel Class I outcome was achieved. Conclusions Cortical ependymomas represent a rare type of ependymoma occurring superficially in the cortex. Morphologically, these tumors are protean, varying from classic to epithelioid, clear cell, and tanycytic. Some also exhibited features typical of AG. Most tumors were low grade and cured with resection. Anaplastic tumors occur and may recur locally despite provision of radiation therapy. Cortical ependymomas frequently, but not always, present with seizures, but despite their high association with epilepsy, none occurred in the temporal lobe in any of the authors’ 9 patients. Overall, CEs appear to have a relatively favorable prognosis compared with other supratentorial ependymomas.

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Sacrococcygeal immature teratoma with malignant ependymoma component

Cited by 12 publications

References 7 publications

Pelvic Ependymoma With Clinical Response to GnRH Analog Therapy

Pelvic Ependymoma With Clinical Response to GnRH Analog Therapy

Sacrococcygeal myxopapillary ependymoma with anaplastic ependymoma component in an infant

Cortical ependymoma: an unusual epileptogenic lesion

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