Saccular Intracranial Aneurysms in Children When Both Parents Are Sporadic or Familial Carriers of Saccular Intracranial Aneurysms

Abstract

Background and purpose: To study the penetrance of saccular intracranial aneurysm (IA) disease in children when both parents carry the disease. Patients and methods: The Kuopio IA Patient and Family Database includes all 4,411 IA patients admitted to the Kuopio University Hospital from its defined Eastern Finnish catchment population since 1980. We fused IA database with hospital diagnoses for IA patients and their 46,021 relatives from a national registry to identify couples concordant for IA disease. Penetrance of IA disease and hypertension were studied in these families. Results: A total of 3,659 IA patients had 1 or more children. In total, 18 couples concordant for the IA disease with a total of 48 children, all born healthy, were identified. Hypertension was diagnosed in 23 (64%) of the 36 parents, and 7 of the 12 sporadic-sporadic couples were concordant for hypertension. Six sporadic-sporadic couples were concordant for subarachnoid haemorrhage (SAH). None of the 24 children to the 12 sporadic-sporadic couples had been diagnosed with SAH or IA disease. Instead, 11 (46%) of the 24 children to the 6 familial-sporadic couples had a diagnosed with SAH or IA disease. Conclusions: Couples concordant for IA disease are uncommon but not exceedingly rare. Biparental sporadic exposure does not seem to increase the risk of a clinically diagnosed IA disease or SAH in the offspring. IAs were common in the children with biparental sporadic-familial exposure.

Pre‐eclampsia, gestational diabetes and hypertensive disorders in patients with intracranial aneurysms: A case–control study

“…However, the impact of pre-eclampsia on later sIA formation or aSAH has not been defined. The Kuopio Intracranial Aneurysm Patient and Family Database (www.kuopi oneur osurg ery.fi) contains all cases of unruptured and ruptured sIAs admitted to the Kuopio University Hospital from a defined Eastern Finnish catchment population since 1980 [11,25,26]. In the present study we used the population-based Kuopio Intracranial Aneurysm Patient and Family Database to analyze the frequency of pre-eclampsia in female patients with sIA disease and in matched female population controls.…”

Should individual timeline and serial CT/MRI panels of all patients be presented in acute brain insult cohorts? A pilot study of 45 patients with decompressive craniectomy after aneurysmal subarachnoid hemorrhage

“…In Kurtelius et al (2019a), the risk of sIA was analyzed in the 48 children of the 18 couples with both parents as verified sIA carriers. Six sIA family trees were illustrated with the timelines of two or three generations since the birth on a linear calendar year axis (1920-2020) [50]. In Kotikoski et al (2021), the linear age timelines of 22 female sIA patients indicated when pre-eclampsia was diagnosed in relation to the diagnosis of unruptured sIA, aSAH, and hypertension [48].…”

Lack of impact of polycystic kidney disease on the outcome of aneurysmal subarachnoid hemorrhage: a matched case-control study

“…The database, including 5250 IA patients at present, has been extensively studied for phenotype on admission, risk factors, concomitant diseases, outcome, and IA genetics. [18][19][20][21][22][23]…”