1993
DOI: 10.1016/s0021-9258(18)82099-3
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Saccharomyces cerevisiae CDC25 (1028-1589) is a guanine nucleotide releasing factor for mammalian ras proteins and is oncogenic in NIH3T3 cells

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Cited by 17 publications
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“…A region of 200-300 amino acids, the RasGEF domain, is shared by all GEFs which act on members of the Ras subfamily, and their activity is specific toward either Ras, Ral, or Rap. The fact that truncated versions of various lengths, containing this RasGEF domain, have been shown to be active RasGEFs in vivo and in vitro (4,(13)(14)(15)(16) confirms that this region indeed represents the Ras-specific guanine nucleotide exchange domain.…”
mentioning
confidence: 83%
“…A region of 200-300 amino acids, the RasGEF domain, is shared by all GEFs which act on members of the Ras subfamily, and their activity is specific toward either Ras, Ral, or Rap. The fact that truncated versions of various lengths, containing this RasGEF domain, have been shown to be active RasGEFs in vivo and in vitro (4,(13)(14)(15)(16) confirms that this region indeed represents the Ras-specific guanine nucleotide exchange domain.…”
mentioning
confidence: 83%
“…In S. cerevisiae, two GDP/GTP exchange factors were identified, Cdc25p and Sdc25p, which are members of the conserved CDC25-like family [for references, see Parmeggiani et al (1993)]. Their catalytic domains were shown to have a GEF activity in vitro (Crechet et al, 1990;Jones et al, 1991;Lai et al, 1993;Chevallier-Multon et al, 1993;Jacquet et al, 1994).…”
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confidence: 99%