Saccharomyces cerevisiae as a vaccine against coccidioidomycosis

Capilla, Javier; Clemons, Karl V.; Liu, Min; Levine, Howard B.; Stevens, David A.

doi:10.1016/j.vaccine.2009.03.030

Cited by 55 publications

(69 citation statements)

References 46 publications

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“…Several studies have evaluated the effectiveness of killed and attenuated fungi as potential vaccines, including S. cerevisiae, which has the potential to protect individuals from the major fungal pathogens. Immunization with heat-killed S. cerevisiae yeasts (HKY) by subcutaneous injection has been shown to be protective against C. albicans (Liu et al 2012a), A. fumigatus (Liu et al 2011a), and the endemic fungus Coccidioides posadasii (Capilla et al 2009). Presumably, immunization with S. cerevisiae offers protection against a variety of fungi because it shares with them common polysaccharide epitopes found on its cell wall.…”

Section: Killed and Attenuated Vaccinesmentioning

confidence: 99%

Fungal Vaccines and Immunotherapeutics

Santos

Levitz

2014

Cold Spring Harbor Perspectives in Medicine

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Section: Killed and Attenuated Vaccinesmentioning

confidence: 99%

Fungal Vaccines and Immunotherapeutics

Santos

Levitz

2014

Cold Spring Harbor Perspectives in Medicine

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“…Недавние исследования показали, что при им-мунизации мышей убитыми прогреванием дрож-жевыми клетками Saccharomyces cerevisiae -heat killed yeasts (HKY) формируется защита против КМ, а также аспергиллеза, кандидоза и криптококко-за [18,20,26]. Авторы предположили, что подоб-ная вакцина является универсальной в отношении микозов.…”

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“…Однако степень защиты мышей от КМ после иммунизации HKY была значительно ниже, чем после применения FKS -вакцины или суб-клеточной фракции, выделенной из механически разрушенных сферул (Т27К) [37]. Стерильного им-мунитета при иммунизации любой из вакцин до-стичь не удалось, в том числе и при вакцинации HKY с различными адъювантами или интерлейки-ном-12 [18,38]. Предполагается, что иммуноген-ные гликаны (глюкуроноксиломаннаны) клеточной стенки, идентичные у сферул Coccidioides spp.…”

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“…Предполагается, что иммуноген-ные гликаны (глюкуроноксиломаннаны) клеточной стенки, идентичные у сферул Coccidioides spp. и S. cerevisiae, являются основными протективны-ми компонентами HKY-вакцины [18]. Неожидан-но оказалось, что стимуляция in vitro иммунных лимфоцитов селезенки, изолированных от вакци-нированных HKY и зараженных Coccidioides spp.…”

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“…Неожидан-но оказалось, что стимуляция in vitro иммунных лимфоцитов селезенки, изолированных от вакци-нированных HKY и зараженных Coccidioides spp. мышей, приводила к значительной пролиферации CD8+T-клеток, но не CD4+T-клеток-хелперов [18]. У иммунизированных HKY мышей были также от-мечены высокие титры антител к глюкану и ман-нану S. cerevisiae.…”

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A literature review presents date obtained during the last years about the strategy of production and protective characteristics of different experimental vaccines against opportunistic and particularly dangerous deep mycoses. The role of T-lymphocytes of Th1 and Th17 types, interactions of CD4+T - and CD8+T-cells in the immune response and maintenance of immunologic memory after immunization with vaccines against mycoses are discussed.

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Glycosylation is an important post-translational modification that is required for structural and stability purposes and functional roles such as signalling, attachment and shielding. Many human pathogens such as bacteria display an array of carbohydrates on their surface that are non-self to the host; others such as viruses highjack the host-cell machinery and present self-carbohydrates sometimes arranged in a non-self more immunogenic manner. In combination with carrier proteins, these glycan structures can be highly immunogenic. During natural infection, glycan-binding antibodies are often elicited that correlate with long-lasting protection. A great amount of research has been invested in carbohydrate vaccine design to elicit such an immune response, which has led to the development of vaccines against the bacterial pathogens Haemophilus influenzae type b, Streptococcus pneumonia and Neisseria meningitidis. Other vaccines, e.g. against HIV-1, are still in development, but promising progress has been made with the isolation of broadly neutralizing glycan-binding antibodies and the engineering of stable trimeric envelope glycoproteins. Carbohydrate vaccines against other pathogens such as viruses (Dengue, Hepatitis C), parasites (Plasmodium) and fungi (Candida) are at different stages of development. This chapter will discuss the challenges in inducing cross-reactive carbohydrate-targeting antibodies and progress towards carbohydrate vaccines.

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Saccharomyces cerevisiae as a vaccine against coccidioidomycosis

Cited by 55 publications

References 46 publications

Fungal Vaccines and Immunotherapeutics

Fungal Vaccines and Immunotherapeutics

Problems of Vaccinal Prevention of Deep Mycoses

Targeting Glycans on Human Pathogens for Vaccine Design

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