Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria

Wei, Bin; Zhang, Bo; Du, Ao-Qi; Zhou, Zhen-Yi; Lu, Dongze; Zhu, Zhong-Hui; Ke, Songze; Wang, Sijia; Yu, Yanlei; Chen, Jianwei; Zhang, Huawei; Jin, Weihua; Wang, Hong

doi:10.1016/j.carbpol.2022.119411

Cited by 28 publications

(11 citation statements)

References 40 publications

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“…The abundance of B. acidifaciens can be enriched by a high soluble fiber diet [44,45]. This species also has various beneficial functions, such as preventing obesity [46], increasing insulin sensitivity [47], and promoting the production of acetate to protect against nonalcoholic steatohepatitis development [48]. In addition, B. acidifaciens-monocolonized mice increase secretory IgA, generate B-cell memory, and thereby strengthen ocular mucosal barrier function [49].…”

Section: Discussionmentioning

confidence: 99%

Agaricus bisporus Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota

Duan

Fan

2023

Foods

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White button mushroom polysaccharide (WMP) has various health-promoting functions. However, whether these functions are mediated by gut microbiota has not been well explored. Therefore, this study evaluated the anti-aging capacity of WMP and its effects on the diversity and composition of gut microbiota in D-galactose-induced aging mice. WMP significantly improved locomotor activity and the spatial and recognition memory of the aging mice. It also alleviated oxidative stress and decreased the pro-inflammatory cytokine levels in the brain. Moreover, WMP increased α-diversity, the short-chain fatty acid (SCFA) level and the abundance of beneficial genera, such as Bacteroides and Parabacteroides. Moreover, its effect on Bacteroides at the species level was further determined, and the enrichments of B. acidifaciens, B. sartorii and B. stercorirosoris were found. A PICRUSt analysis revealed that WMP had a greater impact on the metabolism of carbon, fatty acid and amino acid, as well as the MAPK and PPAR signaling pathway. In addition, there was a strong correlation between the behavioral improvements and changes in SCFA levels and the abundance of Bacteroides, Parabacteroides, Mucispirillum and Desulfovibrio and Helicobacter. Therefore, WMP might be suitable as a functional foods to prevent or delay aging via the directed enrichment of specific species in Bacteroides.

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Section: Discussionmentioning

confidence: 99%

Agaricus bisporus Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota

Duan

Fan

2023

Foods

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“…Moreover, extracting the polysaccharides from foods or herb medicine can be used to develop prebiotics that regulate and remodel the structure of the intestinal microbiota; this approach appears to be both novel and necessary. In herb medicine and common foods, polysaccharides from the leaves of Polygonatum sibiricum regulate the gut microbiota and affect the production of short-chain fatty acids to promote health in mice ( Luo et al, 2022b ); Seaweed polysaccharides exhibit promising potential for the prevention of obesity and gut microbiota dysbiosis by enriching gut bacterial species with fucoidan-degrading ability ( Wei et al, 2022 ). In mushroom, Ganoderma lucidum polysaccharides increase the ratio of Bacteroides / Firmicutes in the intestinal flora and promote the short chain fatty acids production ( Khan et al, 2018 ); Polysaccharide extracted from Inonotus obliquus can modulate gut microbiota by increasing the relative abundance of probiotic bacteria ( Hu et al, 2017 ); Water-insoluble polysaccharide extracted from P. cocos can improve hyperglycemia, hyperlipidemia, and hepatic steatosis in mice by regulating the gut microbiota ( Sun et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Three main metabolites from Wolfiporia cocos (F. A. Wolf) Ryvarden & Gilb regulate the gut microbiota in mice: A comparative study using microbiome-metabolomics

Deng²,

Lei

et al. 2022

Front. Pharmacol.

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Wolfiporia cocos (F. A. Wolf) Ryvarden & Gilb, also known as Poria cocos is an ancient edible and medicinal mushroom that has been valued for thousands of years for its tranquilizing, diuretic, and spleen-enhancing properties. Because of the mushroom’s complex composition, its pharmacological effects have not been fully clarified. Therefore, to expand our knowledge of these effects from a pharmacological perspective and exploit potential medicinal value of fungal mushroom, we extracted three main metabolites from P. cocos, including water-soluble polysaccharides (PCX), water-insoluble polysaccharides (PCY), and triterpenoid saponins (PCZ) for intragastric injection into mice. These injections were made to explore the component’s effects on the mice’s gut microbiota and their metabolomics. The microbiota analysis showed that PCY had the strongest effect on regulating gut microbiota through altering its composition and increasing the number of Lactobacillus (p < 0.01). A total of 1,828 metabolites were detected using metabolomics methods, and the results showed that the three main active metabolites of P. cocos significantly changed the content of short-chain peptides in intestinal metabolites. In conclusion, our study further investigated the pharmacological functions of P. cocos, and revealed the differing effects of its three main metabolites on gut microbiota. The results suggested that PCY is a prominent prebiotic, and provided us with new insights into the potential development of fungal polysaccharides in Chinese traditional medicine.

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“…The fundamental influence of polysaccharides on intestinal microbiota explains its primary mechanism in reducing obesity, which has been studied in many research articles ( 70 , 71 , 84 , 85 ) and reviews ( 86 , 87 ). High-weight molecular polysaccharides isolated from Ganoderma lucidum reduced body weight and fat accumulation in obese mice by altering the intestinal microbiota composition, as indicated by the decreased Firmicutes-to-Bacteroidetes ratios and improved gut barrier function.…”

Section: Polysaccharides Play Vital Roles In the Physiological Status...mentioning

confidence: 99%

Polysaccharides influence human health via microbiota-dependent and -independent pathways

2022

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Polysaccharides are the most diverse molecules and can be extracted from abundant edible materials. Increasing research has been conducted to clarify the structure and composition of polysaccharides obtained from different materials and their effects on human health. Humans can only directly assimilate very limited polysaccharides, most of which are conveyed to the distal gut and fermented by intestinal microbiota. Therefore, the main mechanism underlying the bioactive effects of polysaccharides on human health involves the interaction between polysaccharides and microbiota. Recently, interest in the role of polysaccharides in gut health, obesity, and related disorders has increased due to the wide range of valuable biological activities of polysaccharides. The known roles include mechanisms that are microbiota-dependent and involve microbiota-derived metabolites and mechanisms that are microbiota-independent. In this review, we discuss the role of polysaccharides in gut health and metabolic diseases and the underlying mechanisms. The findings in this review provide information on functional polysaccharides in edible materials and facilitate dietary recommendations for people with health issues. To uncover the effects of polysaccharides on human health, more clinical trials should be conducted to confirm the therapeutic effects on gut and metabolic disease. Greater attention should be directed toward polysaccharide extraction from by-products or metabolites derived from food processing that are unsuitable for direct consumption, rather than extracting them from edible materials. In this review, we advanced the understanding of the structure and composition of polysaccharides, the mutualistic role of gut microbes, the metabolites from microbiota-fermenting polysaccharides, and the subsequent outcomes in human health and disease. The findings provide insight into the proper application of polysaccharides in improving human health.

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Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria

Cited by 28 publications

References 40 publications

Agaricus bisporus Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota

Agaricus bisporus Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota

Three main metabolites from Wolfiporia cocos (F. A. Wolf) Ryvarden & Gilb regulate the gut microbiota in mice: A comparative study using microbiome-metabolomics

Polysaccharides influence human health via microbiota-dependent and -independent pathways

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