Saccharides, oligosaccharides, and polysaccharides nanoparticles for biomedical applications

Seidi, Farzad; Jenjob, Ratchapol; Phakkeeree, Treethip; Crespy, Daniel

doi:10.1016/j.jconrel.2018.06.026

Cited by 104 publications

(44 citation statements)

References 154 publications

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“…Nanomaterial-encapsulated vaccines are thus promising vaccine transport vehicles. CS is a particularly attractive choice for vaccine delivery because of its low immunogenicity, low toxicity, biocompatibility, and biodegradability [ 159 ]. Here we will discuss the gene delivery studies based on CS.…”

Section: Advanced Applications Of Cs-based Nanomaterials For Drug mentioning

confidence: 99%

Chitosan-Based Nanomaterials for Drug Delivery

et al. 2018

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This review discusses different forms of nanomaterials generated from chitosan and its derivatives for controlled drug delivery. Nanomaterials are drug carriers with multiple features, including target delivery triggered by environmental, pH, thermal responses, enhanced biocompatibility, and the ability to cross the blood-brain barrier. Chitosan (CS), a natural polysaccharide largely obtained from marine crustaceans, is a promising drug delivery vector for therapeutics and diagnostics, owing to its biocompatibility, biodegradability, low toxicity, and structural variability. This review describes various approaches to obtain novel CS derivatives, including their distinct advantages, as well as different forms of nanomaterials recently developed from CS. The advanced applications of CS-based nanomaterials are presented here in terms of their specific functions. Recent studies have proven that nanotechnology combined with CS and its derivatives could potentially circumvent obstacles in the transport of drugs thereby improving the drug efficacy. CS-based nanomaterials have been shown to be highly effective in targeted drug therapy.

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Section: Advanced Applications Of Cs-based Nanomaterials For Drug mentioning

confidence: 99%

Chitosan-Based Nanomaterials for Drug Delivery

et al. 2018

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“…Natural polysaccharides with advantages of renewability, biocompatibility, and biodegradability are considered as potential substitutes for traditional fossil resources, which have been used to prepare a variety of functional materials, covering different fields such as biomedicine [1], pharmaceutical [2], food [3], textile [4], environmental protection [5], among others. Starch is one example of polysaccharides that are widely used.…”

Section: Introductionmentioning

confidence: 99%

“…Starch is the main dietary source of carbohydrates for human beings and the most abundant plant-derived storage polysaccharide. As a kind of natural polymer, starch is formed by condensation of glucose units through α-d- (1)(2)(3)(4) and/or α-d-(1-6) glycoside bonds [6]. The design and synthesis of starch-based materials have been a hot topic due to their unique biocompatibility, biodegradability, and film-forming properties [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidant Activity of Cationic 1,2,3-Triazole Functionalized Starch Derivatives

et al. 2020

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In this study, starch was chemically modified to improve its antioxidant activity. Five novel cationic 1,2,3-triazole functionalized starch derivatives were synthesized by using “click” reaction and N-alkylation. A convenient method for pre-azidation of starch was developed. The structures of the derivatives were analyzed using FTIR and 1H NMR. The radicals scavenging abilities of the derivatives against hydroxyl radicals, DPPH radicals, and superoxide radicals were tested in vitro in order to evaluate their antioxidant activity. Results revealed that all the cationic starch derivatives (2a–2e), as well as the precursor starch derivatives (1a–1e), had significantly improved antioxidant activity compared to native starch. In particular, the scavenging ability of the derivatives against superoxide radicals was extremely strong. The improved antioxidant activity benefited from the enhanced solubility and the added positive charges. The biocompatibility of the cationic derivatives was confirmed by the low hemolytic rate (<2%). The obtained derivatives in this study have great potential as antioxidant materials that can be applied in the fields of food and biomedicine.

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“…Hence, functionalization of (polymer) nanomaterials with carbohydrates is a popular strategy to avoid immune response and furthermore may introduce targeting capabilities and increase cellular uptake. 4,7−12 For example, glucose-modified micelles were recently found to be taken up to an increased extent by cells with overexpressed GLUT 1 receptors and to cross the blood–brain barrier in fasting mice. 11 For successful brain uptake, glycaemic control of the mice diet and conjugation on the C6 position instead of the C3 position proved crucial, which suggests a transporter-mediated uptake mechanism.…”

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confidence: 99%

Glucose Single-Chain Polymer Nanoparticles for Cellular Targeting

et al. 2018

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Naturally occurring glycoconjugates possess carbohydrate moieties that fulfill essential roles in many biological functions. Through conjugation of carbohydrates to therapeutics or imaging agents, naturally occurring glycoconjugates are mimicked and efficient targeting or increased cellular uptake of glycoconjugated macromolecules is achieved. In this work, linear and cyclic glucose moieties were functionalized with methacrylates via enzymatic synthesis and used as building blocks for intramolecular cross-linked single-chain glycopolymer nanoparticles (glyco-SCNPs). A set of water-soluble sub-10 nm-sized glyco-SCNPs was prepared by thiol-Michael addition cross-linking in water. Bioactivity of various glucose-conjugated glycopolymers and glyco-SCNPs was evaluated in binding studies with the glucose-specific lectin Concanavalin A and by comparing their cellular uptake efficiency in HeLa cells. Cytotoxicity studies did not reveal discernible cytotoxic effects, making these SCNPs promising candidates for ligand-based targeted imaging and drug delivery.

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Saccharides, oligosaccharides, and polysaccharides nanoparticles for biomedical applications

Cited by 104 publications

References 154 publications

Chitosan-Based Nanomaterials for Drug Delivery

Chitosan-Based Nanomaterials for Drug Delivery

Synthesis and Antioxidant Activity of Cationic 1,2,3-Triazole Functionalized Starch Derivatives

Glucose Single-Chain Polymer Nanoparticles for Cellular Targeting

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