Saccharide–Peptide Hybrid Copolymers as Biomaterials

Metzke, Mark; O’Connor, Naphtali; Maiti, Soumen; Nelson, Edward L.; Guan, Zhibin

doi:10.1002/anie.200501944

Cited by 87 publications

(62 citation statements)

References 16 publications

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“…Considering the various chemistry strategies towards polysaccharide conjugates, the synthesis of new polysaccharide structures associating carbohydrate segments with natural ones such as peptides seems to be achievable. For instance, the synthesis of segmented multiblock copolymers made of short saccharide and peptide units, previously reported by Metzke et al [132] could be applied with true polymeric blocks. The design of glycoprotein-mimics is a current topic of high interest where most of the systems developed so far are graft systems.…”

Section: Resultsmentioning

confidence: 97%

Polysaccharide‐Containing Block Copolymers: Synthesis, Properties and Applications of an Emerging Family of Glycoconjugates

Schatz

Lecommandoux

2010

Macromol. Rapid Commun.

155

123

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While polysaccharide graft copolymers and glycopolymers have been widely studied and used in various applications, linear block copolymer structures combining a polysaccharide segment and a synthetic one have been less described. The limited availability of the polysaccharide reducing-end, the difficulty of finding a common solvent of both blocks and the need sometimes to protect the lateral hydroxyl groups of the polysaccharide chain may explain the relatively low number of studies on this copolymer family despite its potential interest. Polysaccharide block copolymers feature physicochemical properties not only close to those of synthetic block copolymers but also bring an added value such as the biodegradability, the biocompatibility or the bioactivity in some cases. This review aims at presenting the synthetic pathways towards such structures, from the basic polymerization techniques to the most recent ones including controlled/living polymerization mechanisms and also by emphasizing the chemical reactions used to functionalize the reducing-end of the polysaccharide block. The amphiphilic nature of most of the polysaccharide-based block copolymers reported so far gives rise to various self-assembly morphologies in the solid state or in selective solvents. In addition, the rigidity of the polysaccharide block is expected to influence the microphase separation of the block copolymer by increasing the thermodynamic incompatibility between dissimilar blocks. A special interest was drawn to the formation and the properties of polymer vesicles (polymersomes) in aqueous solutions. Polysaccharide block copolymers might represent a new class of biomaterials with potential applications in different fields such as the plastic industry, the detergency and also the pharmaceutics where the design of nanodevices carrying a native polysaccharide chain is of interest for therapy, vaccination and diagnosis purposes.

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Section: Resultsmentioning

confidence: 97%

Polysaccharide‐Containing Block Copolymers: Synthesis, Properties and Applications of an Emerging Family of Glycoconjugates

Schatz

Lecommandoux

2010

Macromol. Rapid Commun.

155

123

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“…Various natural biopolymers, such as collagen, chitosan and elastin-collagen based materials, have been used [9][10][11][12][13]. Various synthetic biodegradable polymers and natural proteins have also been used as scaffolds for cell support [14][15][16]. Electrospinning is a simple and scalable method of producing fibers with diameters ranging from several microns to less than 100 nm [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Electrospun linear polyethyleneimine scaffolds for cell growth

et al. 2007

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“…The materials were shown to be nontoxic, biodegradable, and nonimmunogenic and were tested for possible gene delivery applications and tissue engineering. 45 Inspired by the intriguing properties of elastin, as an important ECM protein, a bioinspired modular synthesis approach to synthesize elastin-mimic polymers (EMPs) to probe the mechanism of elastin elasticity was reported. Three EMPs were synthesized, all based on the abundant sequence of elastin hydrophobic domain (VPGVG) n , that shares identical chemical composition, with differences in peptide sequence.…”

Section: Supramolecular Biomaterials Inspired By Peptides and Peptidementioning

confidence: 99%

Advances in the Development of Supramolecular Polymeric Biomaterials

Goor

Dankers²

2017

Comprehensive Supramolecular Chemistry II

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Saccharide–Peptide Hybrid Copolymers as Biomaterials

Abstract: Au natural: A new class of synthesized biomaterials (saccharide–peptide hybrid copolymers shown) are biodegradable, nontoxic, and nonimmunogenic. The cationic saccharide–peptide hybrid copolymers were also shown to be effective in compacting and transferring plasmid DNA into cells.

Cited by 87 publications

References 16 publications

Polysaccharide‐Containing Block Copolymers: Synthesis, Properties and Applications of an Emerging Family of Glycoconjugates

Polysaccharide‐Containing Block Copolymers: Synthesis, Properties and Applications of an Emerging Family of Glycoconjugates

Electrospun linear polyethyleneimine scaffolds for cell growth

Advances in the Development of Supramolecular Polymeric Biomaterials

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