“Saber-Sheath” Trachea

Callan, Edward; Karandy, Eugene J.; Hilsinger, Raymond L.

doi:10.1177/000348948809700514

Cited by 13 publications

(5 citation statements)

References 9 publications

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“…The tracheal narrowing suggests weakening and collapse, but in COPD, the supporting tracheal cartilage is usually thickened and densely calcified. 7 In our patient, the airway was noted to be stenotic and immobile with a tracheal index of 0.44, compatible with a diagnosis of the saber-sheath trachea (defined as less than 0.67).…”

Section: Discussionsupporting

confidence: 61%

Tracheal and lower airway changes in a patient with mucolipidosis type II

Poore

Prager

Weinman

et al. 2020

Pediatric Pulmonology

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Introduction Mucolipidosis type II (MLII) is a lysosomal storage disease causing systemic deposition of mucopolysaccharides. We describe imaging and bronchoscopy findings not previously reported in the literature in a child with MLII. Case A 9‐year‐old with MLII s/p hematopoietic stem‐cell transplant (HSCT), bronchiectasis, and aspiration presented with recurrent respiratory illnesses. Bronchoscopy and chest computed tomography were performed, showing a saber‐sheath trachea with fixed narrowing and curvature. Discussion This case describes potentially life‐threatening airway distortion in MLII despite HSCT that cannot be ameliorated with tracheostomy. Etiology is unknown but likely due to abnormal deposition causing an immobile, stenotic airway and restricted thorax.

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Section: Discussionsupporting

confidence: 61%

Tracheal and lower airway changes in a patient with mucolipidosis type II

Poore

Prager

Weinman

et al. 2020

Pediatric Pulmonology

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“…5 The narrowing of the intrathoracic trachea in the coronal plane with anteroposterior lengthening is characteristic of the saber-sheath trachea deformity. 6 This structural disorder is primarily associated with COPD and occurs in relation to chronic bronchitis. 6 Lechner investigated a group of 90 men and women with pulmonary function indicative of severe COPD demonstrating that patients with chronic cough and chronic bronchitis exhibited a tendency to intrathoracic coronal narrowing and sagittal widening consistent with sabersheath deformity.…”

Section: Discussionmentioning

confidence: 99%

“…6 This structural disorder is primarily associated with COPD and occurs in relation to chronic bronchitis. 6 Lechner investigated a group of 90 men and women with pulmonary function indicative of severe COPD demonstrating that patients with chronic cough and chronic bronchitis exhibited a tendency to intrathoracic coronal narrowing and sagittal widening consistent with sabersheath deformity. 7 In 1978, Greene established this correlation with clinical COPD when he reported 60 male patients with marked coronal narrowing of the intrathoracic trachea (saber-sheath configuration) with 57 (95%) having clinical evidence of COPD compared to 18% in the control group.…”

Section: Discussionmentioning

confidence: 99%

Saber-sheath trachea in a patient with bronchiolitis obliterans syndrome after lung transplantation

Hayes

2009

Chron Respir Dis

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Chronic rejection remains a major source of morbidity and mortality following lung transplantation. The clinical characteristics of chronic rejection involves bronchiolitis obliterans syndrome (BOS), which leads to progressive airway obstruction. Changes in intrathoracic tracheal dimensions and shape are commonly present in the setting of airway obstruction, leading to the narrowing of the intrathoracic trachea in the coronal plane with anteroposterior lengthening characteristic of the saber-sheath trachea deformity. We present a 64-year-old man who underwent left lung transplantation for idiopathic pulmonary fibrosis who later developed saber-sheath trachea as a result of chronic airway obstruction due to BOS.

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“…The trachea is the site of several pathologies, both acquired and congenital, all affecting the extracellular matrix (Callan et al, 1988;Shivaram et al, 1990). Benign tracheal stenosis following intubation and tracheostomy, "sabersheath trachea" in chronic obstructive pulmonary disease or the elderly, tracheomalacia and granulomas following tracheostomy are diseases commonly seen in medical practice (Callan et al; Shivaram et al).…”

Section: Introductionmentioning

confidence: 99%

Structure and Concentration of Elastic System Fibers in the Trachea of the Rat

et al. 2011

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SUMMARY:The extracellular matrix is a key element in the tracheal morphology and physiology, both in normal and pathological states, yet little is known regarding its composition and organization. Herein we carried out a detailed study of the morphological organization and volumetric density of elastic system fibers in the trachea of Wistar rats. Six Wistar rats at the age of 45 days were used. The trachea was excised following anesthesia with Thiopental and perfusion through the left ventricle with buffered saline followed by formalin solution. Samples were fixed in formaline, embedded in paraffin, and histologically processed. The elastic system fibers were evaluated at light microscopy by using Weigert's resorcin-fuchsin technique after oxidation with oxone. Morphometric studies were performed by the point-counting method. Quantities were expressed (%, mean) as volumetric densities and were determined on 25 random fields for each animal. Elastic system fibers were identified beneath the tracheal mucosa showing mainly a longitudinal profile. There were also some bundles of oblique fibers in this region, forming an irregular network of elastic tissue. Close to the inner surface of the cartilaginous ring, a well defined circular layer is present. The volumetric density of the elastic system fibers in the trachea of Wistar rats is 2.46 ± 0.99%. The data in the present study provides original information regarding the elastic system fibers of the rat trachea, which might be used as a model for studying human major airway morphology. The results reported herein provide the basis for continuous investigations on tracheal extracellular matrix by stereology.

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“Saber-Sheath” Trachea

Cited by 13 publications

References 9 publications

Tracheal and lower airway changes in a patient with mucolipidosis type II

Tracheal and lower airway changes in a patient with mucolipidosis type II

Saber-sheath trachea in a patient with bronchiolitis obliterans syndrome after lung transplantation

Structure and Concentration of Elastic System Fibers in the Trachea of the Rat

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