2014
DOI: 10.1016/s0016-5085(14)61073-8
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Sa1804 Dysregulation of WNT5A/ROR2 Signaling Pathway Characterizes the Progression of Barrett's-Associated Esophageal Adenocarcinoma

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Cited by 2 publications
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“…These genes showed similar trends of expression to CTNNB1 during feather follicle morphogenesis. Wnt5A could activate β-catenin signaling in the presence of FZD4 [ 53 55 ] and suppress the canonical Wnt signaling pathway in the presence of ROR2 via a GSK3-independent pathway, which involves downregulation of β-catenin-induced reporter gene expression [ 56 59 ]. The results suggested that Wnt/β-catenin signaling at the transcriptome level was upregulated in the late stage of feather follicle morphogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…These genes showed similar trends of expression to CTNNB1 during feather follicle morphogenesis. Wnt5A could activate β-catenin signaling in the presence of FZD4 [ 53 55 ] and suppress the canonical Wnt signaling pathway in the presence of ROR2 via a GSK3-independent pathway, which involves downregulation of β-catenin-induced reporter gene expression [ 56 59 ]. The results suggested that Wnt/β-catenin signaling at the transcriptome level was upregulated in the late stage of feather follicle morphogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…This is the first report to show that metformin inhibited ROR2 activation. ROR2 correlates with a poor prognosis in various cancer types (37)(38)(39), cell migration/ invasion and metastasis (40)(41)(42); therefore, it has potential as a novel drug target in cancer therapy.…”
Section: Discussionmentioning
confidence: 99%