Sa1386 EUS-Guided Biopsies for Molecular Testing of Pancreatic Cancer: Optimization of Experimental Parameters for DNA and miRNA Extraction and Analysis

Benešová, Lucie; Belšánová, Barbora; Cuperkova, Romana; Bunganič, Bohuš; Dvořáková, Tereza; Zavoral, Miroslav; Minárik, Marek

doi:10.1016/s0016-5085(14)60988-4

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“…Benesova et al . [ 11 ] studied the utility of EUS-FNA and core biopsy samples for DNA and in particular, miRNA testing in of 65 pancreatic cancer patients. KRAS mutations were detected by denaturing capillary electrophoresis, miRNA presence was quantified by real-time PCR of miRNA-specific cDNA obtained by a standard reverse-transcription from total RNA extracted from samples.…”

Section: Molecular and Other Markers On Cytology/histology Obtained Bmentioning

confidence: 99%

Endoscopic ultrasound comes of age: Mature, established, creative and here to stay!

Bhutani

2014

Endosc Ultrasound

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Research in endoscopic ultrasound (EUS) is alive and kicking! This paper will present recent interesting developments in EUS based on research presented at the Digestive Disease Week (DDW) held in Chicago in 2014. Endosonographers are looking at various techniques to improve yield of fine needle aspiration and core biopsies, assess circulating tumor cells, apply EUS for personalized medicine and develop devices to ensure the adequacy of sampling. EUS may open new vistas in understanding of neurogastroenterology and gastrointestinal motility disorders as discussed in this paper. EUS guided drainage of pancreatic fluid collections, bile duct and gallbladder is feasible, and many randomized trials are being done to compare different techniques. EUS guided delivery of fiducials, drugs, coils or chemo loaded beads in possible. EUS has come off age, has matured and is here to stay! The DDW in 2014 in Chicago was a very active year for EUS. There were numerous papers on different aspects of EUS, some perfecting and improving old techniques, others dealing with randomized trials and many with novel concepts. In this paper, I will highlight some of the papers that were presented. It is not possible to discuss all the abstracts in detail. I have, therefore, chosen selected papers in different aspects of EUS to give the readers a flavor of the kind of research that was presented at DDW.

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Section: Molecular and Other Markers On Cytology/histology Obtained Bmentioning

confidence: 99%

Endoscopic ultrasound comes of age: Mature, established, creative and here to stay!

Bhutani

2014

Endosc Ultrasound

View full text Add to dashboard Cite

show abstract

Sa1386 EUS-Guided Biopsies for Molecular Testing of Pancreatic Cancer: Optimization of Experimental Parameters for DNA and miRNA Extraction and Analysis

Cited by 1 publication

References 0 publications

Endoscopic ultrasound comes of age: Mature, established, creative and here to stay!

Endoscopic ultrasound comes of age: Mature, established, creative and here to stay!

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