Sa1239 Modulation of Thiopurine Metabolism by Anti-TNF Therapy

Yoon, Jessica L.; Huang, Brian; Melmed, Gil Y.; Amin, Jaimin; Ippoliti, Andrew; Dubinsky, Marla C.; Khanna, Puja P.; Fleshner, Phillip; McGovern, Dermot; Targan, Stephan; Vasiliauskas, Eric A.; Shi, David

doi:10.1016/s0016-5085(14)60843-x

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Allopurinol Supplementation1

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2015

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“…49,50,83,84 In the Study of Immunomodulator Naive in Crohn's Disease (SONIC) Trial in moderate-to-severe patients with CD who had not yet undergone previous immunosuppressive or biologic therapy, therapeutic efficacy was compared between infliximab and AZA either alone or in combination. 87,88 This suggests that in addition to suppression of immunogenicity, the greater efficacy of combination anti-TNF and thiopurine may be due to increased 6-TGN levels. 85 It has been proposed that reduced immunogenicity to biologics in concomitant thiopurine and anti-TNF therapy lead to the improved therapeutic response with combination therapy.…”

Section: Allopurinol Supplementationmentioning

confidence: 99%