Sa1179 High Compliance With Guideline Recommendations on Post-ERCP Pancreatitis (PEP) Prevention Is Associated With Low PEP Incidence: Results From a National Spanish Survey

Riesco, José María; Pérez-Miranda, Manuel; González-Húix, Ferrán; Álvarez, Alberto; Pérez-Roldán, Francisco; Gornals, Joan B.

doi:10.1016/j.gie.2016.03.343

Cited by 3 publications

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“…Diagnostic criteria for post-ERCP pancreatitis [7] was: post-ERCP serum amylase level was over 3 times than the normal level, and abdominal pain or abdominal pain exacerbation lasted for more than 24 hours. Diagnostic criteria for hyperamylasemia [8] was: serum amylase level of the patient was higher than normal level for 12 consecutive hours after ERCP without obvious symptoms of abdominal pain.…”

Section: Methodsmentioning

confidence: 99%

Risk Factors for Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis and the Effect of Octreotide Combined with Nonsteroidal Anti-Inflammatory Drugs on Preventing Its Occurrence

et al. 2018

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BackgroundThe aim of this study was to explore the risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and investigate the effect of octreotide combined with nonsteroidal anti-inflammatory drugs on preventing its occurrence.Material/MethodsA total of 139 patients undergoing ERCP in our hospital from May 2016 to April 2017 were retrospectively analyzed, and divided into an observation group (n=67) (octreotide + indomethacin) and a control group (n=72) (no preventive drugs). The preoperative and postoperative inflammatory cytokines such as tumor necrosis factor-α (TNF)-α, interleukin-6 (IL-6) and IL-8, and serum amylase levels were measured, and the incidence of pancreatitis and hyper amylasemia were monitored.ResultsSerum amylase level was increased significantly 3 hours after operation in both groups with significantly higher level in the control group compared to the observation group. After 24 hours, serum amylase in the observation group was decreased to preoperative level, whereas it was still higher than preoperative in the control group (P<0.05). Regarding the levels of TNF-α, IL-6, IL-8, and visual analogue scale, they were significantly increased in both groups after operation with significantly higher levels in the control group compared to the observation group (P<0.05). Furthermore, logistic regression analysis showed that difficult intubation, pancreatic duct angiography, surgery for a long time, and the history of previous pancreatitis were risk factors for post-ERCP pancreatitis (P<0.05).ConclusionsDifficult intubation, pancreatic duct angiography, surgery for a long time, and the history of previous pancreatitis were risk factors for post-ERCP pancreatitis. Octreotide combined with non-steroidal anti-inflammatory drugs can reduce the pain of patients with abdominal pain as well as the incidence of postoperative pancreatitis, indicating that they might be effective preventative approaches for pancreatitis.

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Section: Methodsmentioning

confidence: 99%

Risk Factors for Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis and the Effect of Octreotide Combined with Nonsteroidal Anti-Inflammatory Drugs on Preventing Its Occurrence

et al. 2018

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“…The correct identification of high-risk patients and the compliance with the established guidelines are obviously associated with a lower PEP incidence [9]. Therefore, personal experience in ERCP and confidence should not be motives for diverging from evidence-based recommendations.…”

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confidence: 99%

Prophylaxis of Post-ERCP Pancreatitis: The Gap between Evidence-Based Guidelines and Clinical Practice

Rio-Tinto

Devière

2018

GE Port J Gastroenterol

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Nonsteroidal Anti-inflammatory Drugs for the Prevention of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis

Zuo,

Li,

Zhang

et al. 2024

Dig Dis Sci

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Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) remains the most frequent and severe complication following ERCP, elevating both patient suffering and healthcare costs, and posing challenges to the advancement of ERCP techniques. Empirical evidence supports the prophylactic use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of PEP, especially in high-risk populations, as endorsed by both the American Society for Gastrointestinal Endoscopy (ASGE) and the European Society for Gastrointestinal Endoscopy (ESGE). However, the prophylactic efficacy of NSAIDs in average-risk individuals, alongside the ideal drug selection, dosing, and timing of NSAID administration, remains to be elucidated. Furthermore, the synergistic preventive potential of NSAIDs when integrated with other interventions, such as hydration, pancreatic stenting, somatostatin administration, sublingual nitrate application, and epinephrine, warrants further clarification. In this paper, we conduct an exhaustive review of the prophylactic effect and clinical administration of NSAIDs for PEP. We comprehensively synthesize findings from clinical trials investigating NSAIDs, both in monotherapy and combination regimens, for PEP prevention. Additionally, we scrutinize the current landscape of NSAID usage in clinical practice and evaluate their cost-effectiveness. Future research should concentrate on refining NSAID prophylaxis strategies for PEP in patients at different risk levels, while also enhancing adherence to clinical guidelines and alleviating the issue of NSAID cost inflation.

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Sa1179 High Compliance With Guideline Recommendations on Post-ERCP Pancreatitis (PEP) Prevention Is Associated With Low PEP Incidence: Results From a National Spanish Survey

Cited by 3 publications

References 0 publications

Risk Factors for Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis and the Effect of Octreotide Combined with Nonsteroidal Anti-Inflammatory Drugs on Preventing Its Occurrence

Risk Factors for Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis and the Effect of Octreotide Combined with Nonsteroidal Anti-Inflammatory Drugs on Preventing Its Occurrence

Prophylaxis of Post-ERCP Pancreatitis: The Gap between Evidence-Based Guidelines and Clinical Practice

Nonsteroidal Anti-inflammatory Drugs for the Prevention of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis

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