Sa1168 High-Resolution Microendoscopy (HRME) in the Detection of Anal Intraepithelial Neoplasia: A Quantitative Approach to Optimize Diagnostic Accuracy

Varela, Benigno R.; Shin, Dongsuk; Perl, Daniel P.; Zhou, Elinor; Lee, Michelle H.; Protano, Marion-Anna; Richards‐Kortum, Rebecca; Gaisa, Michael; Anandasabapathy, Sharmila

doi:10.1016/s0016-5085(14)60772-1

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10 62 images were selected from the database and analyzed. Evaluation of eleven nuclear features yielded promising results, with a combination of three primary measurements yielding a sensitivity/specificity of 90% and 88%.…”

Section: Resultsmentioning

confidence: 99%

Applications and Advancements in the Use of High-resolution Microendoscopy for Detection of Gastrointestinal Neoplasia

Louie

Richards‐Kortum

Anandasabapathy

2014

Clinical Gastroenterology and Hepatology

Self Cite

View full text Add to dashboard Cite

The high-resolution microendoscope (HRME) is a novel imaging modality that allows real-time epithelial imaging at subcellular resolution. Used in concert with any standard endoscope, this portable, low cost, ‘optical biopsy’ technology has the ability to provide images of cellular morphology during a procedure. This technology has been the subject of a number of studies investigating its use in screening and surveillance of a range of gastrointestinal neoplasia, including esophageal adenocarcinoma(EAC), esophageal squamous cell cancer(ESCC), colorectal neoplasia(CRC) and anal neoplasia. These studies have shown that HRME is a modality that consistently provides high specificity, negative predictive value, and accuracy across different diseases. In addition, they have illustrated that HRME users can be relatively easily trained in a short period of time and that users have demonstrated solid inter-rater reliability. These features make HRME a potential complement to high definition white light imaging, narrow band imaging and other ‘red flag technologies’ in facilitating real-time clinical diagnosis, endoscopic therapy and margin determination. Further clinical validation is needed to determine whether this translates to reduced procedure times, pathology costs, and follow up procedures. Finally, the HRME has a relatively simple design compared to other similar technologies, making it portable, simple to maintain, and low cost. This may allow the HRME device to function in both advanced care settings as well as in places with less resources and specialized support systems. As a whole, the HRME device has shown good performance along with low-cost and portable construction, and its application in different conditions and settings has been promising.

show abstract

Section: Resultsmentioning

confidence: 99%

Applications and Advancements in the Use of High-resolution Microendoscopy for Detection of Gastrointestinal Neoplasia

Louie

Richards‐Kortum

Anandasabapathy

2014

Clinical Gastroenterology and Hepatology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In another study by the same group, 62 images from the data based were analyzed to identify quantitative features, that could potentially increase the diagnostic utility of HRME during anoscopy. A total of 11 nuclear features were studied, with a combination of 3 primary measurements yielding a sensitivity of 90% and a specificity of 88% for diagnosing HSIL [73].…”

Section: Hrme and Anal Cancermentioning

confidence: 99%

Progress and Challenges of Global High-Resolution Endoscopy

Bhushan¹,

Richards²,

Anandasabapathy³

2020

Int Arch Intern Med

View full text Add to dashboard Cite

In recent years, gastrointestinal endoscopy has seen an influx of high-resolution endoscopic technologies that are capable of providing optical biopsies of the epithelial surface in real time. Upcoming high-resolution endoscopy techniques are CLE, OCT, EC and HRME. Powered by automated diagnostic algorithms and more-cost effective alternatives, these high-resolution endoscopic technologies have the potential to not only facilitate real-time decision making, but also improve screening and surveillance of gastrointestinal cancers globally. This review discusses the most promising upcoming optical biopsy technologies and their clinical applications, along with the current trends, challenges and future directions.

show abstract