S91intervention Effects Mitigate the Association Between Polygenic Risk for Alcohol Use and Inhibitory Control in Middle Childhood

Oro, Veronica; Clifford, Sierra; Shaw, Daniel S.; Wilson, Melvin N.; Lemery‐Chalfant, Kathryn

doi:10.1016/j.euroneuro.2019.08.092

Cited by 1 publication

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“…We have recently shown, for example, that the Family Check-Up increases children's temperamental inhibitory control across childhood, and inhibitory control mediates prevention effects on adolescent outcomes including internalizing and externalizing problems (Hentges et al, 2020). Furthermore, genetic risk for child psychopathology is ameliorated for children whose families received the intervention; those at high genetic risk in the control group had lower levels of observed childhood effortful control, whereas levels of effortful control were "repaired" for children in the intervention group (Oro et al, 2019).…”

Section: Implications For Clinical Issuesmentioning

confidence: 99%

Childhood inhibition predicts adolescent social anxiety: Findings from a longitudinal twin study

et al. 2022

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An enduring issue in the study of mental health is identifying developmental processes that explain how childhood characteristics progress to maladaptive forms. We examine the role that behavioral inhibition (BI) has on social anxiety (SA) during adolescence in 868 families of twins assessed at ages 8, 13, and 15 years. Multimodal assessments of BI and SA were completed at each phase, with additional measures (e.g., parenting stress) for parents and twins. Analyses were conducted in several steps: first, we used a cross-lagged panel model to demonstrate bidirectional paths between BI and SA; second a biometric Cholesky decomposition showed that both genetic and environmental influences on childhood BI also affect adolescent SA; next, multilevel phenotypic models tested moderation effects between BI and SA. We tested seven potential moderators of the BI to SA prediction in individual models and included only those that emerged as significant in a final conditional model examining predictors of SA. Though several main effects emerged as significant, only parenting stress had a significant interaction with BI to predict SA, highlighting the importance of environmental moderators in models examining temperamental effects on later psychological symptoms. This comprehensive assessment continues to build the prototype for such developmental psychopathology models.

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Section: Implications For Clinical Issuesmentioning

confidence: 99%