Abstract:Background:Multiple Myeloma (MM), a disease characterized by a clonal expansion of plasma cells, still remains incurable with current treatment options. The genetic engineering of T lymphocytes with chimeric antigen receptors (CAR) has recently emerged as a promising therapeutic approach and BCMA has shown to be a good MM‐specific antigenic target. Despite its specificity, the intensity of BCMA is variable in MM patients and may not be uniform across different subclonal populations which might explain why firs… Show more
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