Modelling Lung Disease in Vitro/Vivo 2019 Help me understand this report
S90 A novel organotypic model of bronchial dysplasia for preclinical screening of potential therapeutic agents for early squamous lung cancer (SQC)
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“…For example, the reproduction of a genetic lesion (CDKN2A disruption) in vitro was shown to induce dysregulation in SOX2 production in the HBEC ALI model. This provided sufficient predictive validity to human bronchial dysplasia to enable preclinical screens of novel agents to treat squamous lung cancer (Porter et al, 2019).…”
Section: D Air-liquid Interface Respiratory Epithelium Modelsmentioning
confidence: 99%
“…For example, the reproduction of a genetic lesion (CDKN2A disruption) in vitro was shown to induce dysregulation in SOX2 production in the HBEC ALI model. This provided sufficient predictive validity to human bronchial dysplasia to enable preclinical screens of novel agents to treat squamous lung cancer (Porter et al, 2019).…”
Section: D Air-liquid Interface Respiratory Epithelium Modelsmentioning
confidence: 99%
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