S87. Depression During Pregnancy is Associated With an Altered Gut Microbiome

Association between gut microbiota and its functional metabolites with prenatal depression in women

“…However, our results found that there was no statistical difference in alpha diversity and beta diversity between the prenatal depression group and the controls, which is consistent with the findings of Zheng et al (2016) . Bernabe et al (2020) also indicated that prenatal depression was not associated with the Shannon diversity index, but was negatively correlated with beta diversity, which was partially consistent with our results. However, some studies found that the diversity and richness of gut microbiota in depressed patients decreased ( Jiang et al, 2015 ; J. R. Kelly et al, 2016 ), while other studies found that the alpha diversity in the active-MDD group increased ( Jiang et al, 2015 ).…”

“…In addition, numerous studies have shown that the gut microbiota interacts with the brain through multiple pathways in the microbiota-gut-brain axis and that these interactions play an important role in the occurrence and development of depression ( Foster and Neufeld, 2013 ; Luna and Foster, 2015 ). Recently, Bernabe et al (2020) found that Paraprevotella was enriched and Faecalibacterium was depleted in women with antenatal depression in a population study. Previous animal studies also found that germ-free mice transplanted with fecal samples from patients with “depressive microbiota” showed depressive-like behavior, which partly explained the causal role of gut microbiota in the development of depression ( J. Kelly et al, 2016 ; Zheng et al, 2016 ).…”

Varied Composition and Underlying Mechanisms of Gut Microbiome in Neuroinflammation

“…Over the past few years, increasing evidence has suggested a strong link between the microbiome composition and the development of mental disorders, including depression. The fecal microbiome composition in patients diagnosed with MDD has been found to be different compared to healthy controls [329][330][331] (reviewed by [332][333][334][335]) with increased Proteobacteria, Bacteroidetes, and Actinobacteria and fewer Firmicutes in MDD patients [329].…”