S696 Retrospective Review of Gastrointestinal Bleeding in COVID-19 Patients Admitted to the Intensive Care Unit

Khalid, Sameeha; Chaudhry, Hunza; Wang, Yichen; Yan, Yueqi; Chintanaboina, Jayakrishna

doi:10.14309/01.ajg.0000859424.05192.97

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reduction in platelet blood count has been related to withdrawal from circulation by disseminated thrombotic events [33]. In the present study, the mean platelet count was slightly smaller in non-survivor patients (p = 0.317), disagreeing with other studies [34,35]. However, this corroborated the study of Jemaa et al (2022), which compared platelet count in ICU survivors and non-survivors [32].…”

Section: Plos Onecontrasting

confidence: 98%

“…Although, the NLR parameter has been more largely evaluated in the literature. Khalid et al (2022) compared hematological parameters between patients with COVID-19 and a control group of healthy individuals and observed that the absolute count of lymphocytes, PLR, and NLR was significantly higher in cases of severe disease [35]. Kosidło et al (2023), in a recent literature review, reinforce the role of NLR as a predictor of the severity of inflammation in the course of COVID-19.…”

Section: Plos Onementioning

confidence: 98%

See 1 more Smart Citation

Evaluation of hematological changes and immune response biomarkers as a prognostic factor in critical patients with COVID-19

Manaças,

Amorim,

Aguila

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

COVID-19 disease has been a challenge for health systems worldwide due to its high transmissibility, morbidity, and mortality. Severe COVID-19 is associated with an imbalance in the immune response, resulting in a cytokine storm and a hyperinflammation state. While hematological parameters correlate with prognosis in COVID patients, their predictive value has not been evaluated specifically among those severely ill. Therefore, we aim to evaluate the role of hematological and immune response biomarkers as a prognostic factor in critically ill patients with COVID-19 admitted to the intensive care unit. From May 2020 to July 2021, a retrospective cohort study was conducted in a reference hospital in Manaus, which belongs to the Brazilian public health system. This study was carried out as single-center research. Clinical and laboratory parameters were analyzed to evaluate the association with mortality. We also evaluated the role of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein-to-lymphocyte ratio (CLR). We gathered information from medical records, as well as from prescriptions and forms authorizing the use of antimicrobial medications. During the study period, 177 patients were included, with a mean age of 62.58 ± 14.39 years. The overall mortality rate was 61.6%. Age, mechanical ventilation (MV) requirement, leukocytosis, neutrophilia, high c-reactive protein level, NLR, and CLR showed a statistically significant association with mortality in the univariate analysis. In the multivariate logistic regression analysis, only MV (OR 35.687, 95% CI: 11.084–114.898, p< 0.001) and NLR (OR 1.026, 95% CI: 1.003–1.050, p = 0.028) remained statistically associated with the outcome of death (AUC = 0.8096). While the need for mechanical ventilation is a parameter observed throughout the hospital stay, the initial NLR can be a primary risk stratification tool to establish priorities and timely clinical intervention in patients with severe COVID-19 admitted to the ICU.

show abstract

Section: Plos Onecontrasting

confidence: 98%

Section: Plos Onementioning

confidence: 98%

Evaluation of hematological changes and immune response biomarkers as a prognostic factor in critical patients with COVID-19

Manaças,

Amorim,

Aguila

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…During the incubation period and early phase of COVID-19, the lymphocyte count is normal or slightly decreased. However, after the onset of the main symptoms, there is a marked lymphopenia and hyperactivation of platelets, which leads to thrombocytopenia [16,17]. The platelet-to-lymphocyte ratio is an easily obtainable ratio from the CBD panel.…”

Section: Introductionmentioning

confidence: 99%

Platelet-to-lymphocyte ratio as a prognostic biomarker for COVID-19 severity: a single center retrospective data analysis and systematic review with meta-analysis of 187 studies

Matuszewski,

Szarpak,

Pruc

et al. 2023

Disaster Emerg Med J

View full text Add to dashboard Cite

show abstract

S696 Retrospective Review of Gastrointestinal Bleeding in COVID-19 Patients Admitted to the Intensive Care Unit

Cited by 2 publications

References 0 publications

Evaluation of hematological changes and immune response biomarkers as a prognostic factor in critical patients with COVID-19

Evaluation of hematological changes and immune response biomarkers as a prognostic factor in critical patients with COVID-19

Platelet-to-lymphocyte ratio as a prognostic biomarker for COVID-19 severity: a single center retrospective data analysis and systematic review with meta-analysis of 187 studies

Contact Info

Product

Resources

About