S56 Measures of inflammation, complement activation and coagulation in patients with COVID-19

Wiffen, Laura; Brown, Theodore G.; Chauhan, Milan; Fox, Lauren; Glaysher, Sharon; Elliott, Scott; D’Cruz, Leon; Nunn, Miles A.; Higenbottam, T W; Chauhan, AJ

doi:10.1136/thorax-2021-btsabstracts.62

Cited by 2 publications

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“…Promising preclinical effects have now been shown in a preclinical model of bullous pemphigoid [202]. Similarly, nomacopan is being developed against exuberant pulmonary inflammation in COVID‐19, in which elevated plasma levels of leukotriene B4 and complement factor 5a have been detected [203]. Clinical trials have been announced [204], but no data have been published in this indication.…”

Section: Immunomodulationmentioning

confidence: 99%

The tick and I: Parasite‐host interactions between ticks and humans

Schön

2022

J Deutsche Derma Gesell

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Summary Ticks, particularly hard ticks (Ixodidae), which are among the most important vectors of dangerous infectious agents, feed on their hosts for extended periods of time. With this lifestyle, numerous adaptations have evolved in ticks and their hosts, the pharmacological importance of which is increasingly being recognized. Many bioactive substances in tick saliva are being considered as the basis of new drugs. For example, components of tick cement can be developed into tissue adhesives or wound closures. Analgesic and antipruritic salivary components inhibit histamine or bradykinin, while other tick‐derived molecules bind opioid or cannabinoid receptors. Tick saliva inhibits the extrinsic, intrinsic, or common pathway of blood coagulation with implications for the treatment of thromboembolic diseases. It contains vasodilating substances and affects wound healing. The broad spectrum of immunomodulatory and immunosuppressive effects of tick saliva, such as inhibition of chemokines or cellular immune responses, allows development of drugs against inflammation in autoimmune diseases and/or infections. Finally, modern vaccines against ticks can curb the spread of serious infections. The medical importance of the complex tick‐host interactions is increasingly being recognized and translated into first clinical applications. Using selected examples, an overview of the mutual adaptations of ticks and hosts is given here, focusing on their significance to medical advance.

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Section: Immunomodulationmentioning

confidence: 99%

The tick and I: Parasite‐host interactions between ticks and humans

Schön

2022

J Deutsche Derma Gesell

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“…In einem präklinischen Modell des Bullösen Pemphigoids wurden inzwischen erfolgversprechende präklinische Wirkungen gezeigt [202]. Ebenso wird Nomacopan gegen überschießende pulmonale Entzündungen bei COVID-19, bei denen erhöhte Plasmaspiegel von Leukotrien B4 und Komplementfaktor 5a gemessen wurden [203], entwickelt. Klinische Studien wurden angekündigt [204], aber in dieser Indikation wurden noch keine Daten publiziert.…”

Section: Immunmodulationunclassified

Die Zecke und ich: Parasiten‐Wirt‐Interaktionen zwischen Zecken und Menschen

Schön

2022

J Deutsche Derma Gesell

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Abbildung 1 Lebenszyklus des Gemeinen Holzbocks (Ixodes ricinus). Vollgesogenes Weibchen von dorsal (a). Vollgesogenes Weibchen von ventral (b). Reifer Samen des Wunderbaumes (Ricinus communis) zum Vergleich (c). Das vollgesogene Weibchen lässt sich von seinem letzten Wirt abfallen und legt in der Streuschicht am Boden zwischen 1000 und 2000 Eier, aus denen circa 0,5 mm große Larven schlüpfen (d). Diese lauern in niedriger Vegetation auf den ersten Wirt, meist kleinere Tiere. Die Larven häuten sich zu achtbeinigen, etwa 1 mm langen Nymphen, die den zweiten Wirt befallen. Nach dem Saugakt erfolgt die zweite Häutung zur erwachsenen Zecke ebenfalls in der Streuschicht am Boden. Weibchen und Männchen kopulieren schon in der Vegetation oder auf dem letzten Wirt.

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S56 Measures of inflammation, complement activation and coagulation in patients with COVID-19

Cited by 2 publications

References 0 publications

The tick and I: Parasite‐host interactions between ticks and humans

The tick and I: Parasite‐host interactions between ticks and humans

Die Zecke und ich: Parasiten‐Wirt‐Interaktionen zwischen Zecken und Menschen

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