S550 Naloxegol and Naldemedine in the Treatment of Persistent Opioid-Induced Constipation (OIC) in Patients With Cancer Pain: A Systematic Review

Abstract

0.009) H 2 baseline (14.1 6 7.1 ppm (mean 6 SD)) than controls (6.8 6 3.9 ppm). The IBS group baseline CH 4 (12.1 1 11.5 ppm) was 36% higher than the healthy controls (7.8 6 7.8 ppm) but didn't reach statistical significance (p 5 0.3) (Table ) Conclusion: Given the connection between diverse gut microflora and health, finding mechanisms to influence this environment is favorable. Prebiotic fibers, like 2'-FL, have the potential to enrich this microenvironment through microbial fermentation. However, in order to gain such a health benefit, the prebiotic must be metabolized by the host's gut microflora. Our data demonstrate the individualized nature of host-microbiome fermentation response across subjects and support the use of a more personalized approach. Daily breath analysis has the potential to identify microbial responders, as well as being used to help optimize dosing and tolerance over time.