S54 ‘Long-COVID’: the need for multi-disciplinary working

Saigal, Anita; Naidu, SB; Shah, AJ; Brill, SE; Jarvis, Hannah; Goldring, James; Hurst, JR; Lipman, Marc; Mandal, Swapna

doi:10.1136/thorax-2020-btsabstracts.59

Cited by 7 publications

(10 citation statements)

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“…Based on the duration of follow-up (<3 months, >3 months), there were no significant differences in frequency of GI symptoms between these two groups. The frequency of GI symptoms in studies reporting a follow-up of less than 3 months was 0.11 (95% CI, 0.02–0.38, I 2 = 98%) while for studies with more than 3 months of follow-up it was 0.12 (95% CI, 0.06–0.22, I 2 = 100%) 13 , 14 , 27 , 28 , 39 , 40 , 42 , 45 , 48 , 49 , 51 , 55 , 59 , 60 ( Supplemental Figure 5 ). Subgroup analysis on the basis of mode of follow-up suggested a slightly higher frequency of symptoms with telephonic follow-up [0.14 (95% CI, 0.06–0.31, I 2 = 98%)] as compared to in person follow-up [0.04 (95% CI, 0.01–0.19, I 2 = 98%)] 13 , 14 , 27 , 28 , 39 , 40 , 42 , 45 , 48 , 49 , 51 , 55 , 59 , 60 ( Supplemental Figure 6 ).…”

Section: Resultsmentioning

confidence: 98%

“…Table 1 shows the details of the included studies with the study design, type of population, symptoms, duration, and the information provided. 13 – 62 Supplemental Table 2 shows the excluded studies with reasons of exclusion.…”

Section: Resultsmentioning

confidence: 99%

“…The overall frequency of GI symptoms was reported in 14 studies involving 296,487 patients. 13 , 14 , 27 , 28 , 39 , 40 , 42 , 45 , 48 , 49 , 51 , 55 , 59 , 60 The frequency of overall GI symptoms in patients with COVID-19 was 0.12 [95% confidence interval (CI), 0.06–0.22, I 2 = 99%] ( Figure 2 ). The frequency of GI symptoms in long COVID was reported in 12 studies (158,731 patients).…”

Section: Resultsmentioning

confidence: 99%

“…The frequency of GI long-COVID symptoms in patients with severe COVID-19 was 0.13 (95% CI, 0.04–0.34, I 2 = 99%) (five studies, 19,067 patients) 40 , 48 , 49 , 51 , 60 ( Supplemental Figure 1 ). The frequency was 0.14 (95% CI, 0.05–0.34, I 2 = 98%) in studies reporting mixed disease severity (severe as well as non-severe disease) 13 , 14 , 39 , 42 , 45 , 55 , 59 ( Supplemental Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The frequency of GI manifestations in patients with long COVID as per WHO definition was 0.28 (95% CI, 0.15–0.46, I 2 = 97%) 39 , 40 , 42 , 45 , 51 , 52 , 55 ( Supplemental Figure 3 ). The frequency of GI manifestations in patients with COVID-19 as per NICE/CDC definition was 0.14 (95% CI, 0.06–0.28, I 2 = 99%) 13 , 14 , 39 , 40 , 42 , 45 , 48 , 49 , 51 , 59 , 60 ( Supplemental Figure 4 ). The frequency of GI manifestations in patients with long COVID as per NICE/CDC definition was 0.26 (95% CI, 0.11–0.50, I 2 = 96%) 13 , 14 , 39 , 40 , 42 , 45 , 51 , 52 , 53 , 55 ( Supplemental Figure 4 ).…”

Section: Resultsmentioning

confidence: 99%

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Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

Choudhury

Tariq

Jena

et al. 2022

Therap Adv Gastroenterol

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Background: Prolonged symptoms after COVID-19 are an important concern due to the large numbers affected by the pandemic. Objectives: To ascertain the frequency of gastrointestinal (GI) manifestations as part of long GI COVID. Design: A systematic review and meta-analysis of studies reporting GI manifestations in long COVID was performed. Data Sources and Methods: Electronic databases (Medline, Scopus, Embase, Cochrane Central Register of Controlled Trials, and Web of Science) were searched till 21 December 2021 to identify studies reporting frequency of GI symptoms in long COVID. We included studies reporting overall GI manifestations or individual GI symptoms as part of long COVID. We excluded pediatric studies and those not providing relevant information. We calculated the pooled frequency of various symptoms in all patients with COVID-19 and also in those with long COVID using the inverse variance approach. All analysis was done using R version 4.1.1 using packages ‘meta’ and ‘metafor’. Results: A total of 50 studies were included. The frequencies of GI symptoms were 0.12 [95% confidence interval (CI), 0.06–0.22, I2 = 99%] and 0.22 (95% CI, 0.10–0.41, I2 = 97%) in patients with COVID-19 and those with long COVID, respectively. The frequencies of abdominal pain, nausea/vomiting, loss of appetite, and loss of taste were 0.14 (95% CI, 0.04–0.38, I2 = 96%), 0.06 (95% CI, 0.03–0.11, I2 = 98%), 0.20 (95% CI, 0.08–0.43, I2 = 98%), and 0.17 (95% CI, 0.10–0.27, I2 = 95%), respectively, after COVID-19. The frequencies of diarrhea, dyspepsia, and irritable bowel syndrome were 0.10 (95% CI, 0.04–0.23, I2 = 98%), 0.20 (95% CI, 0.06–0.50, I2 = 97%), and 0.17 (95% CI, 0.06–0.37, I2 = 96%), respectively. Conclusion: GI symptoms in patients were seen in 12% after COVID-19 and 22% as part of long COVID. Loss of appetite, dyspepsia, irritable bowel syndrome, loss of taste, and abdominal pain were the five most common GI symptoms of long COVID. Significant heterogeneity and small number of studies for some of the analyses are limitations of the systematic review.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

Choudhury

Tariq

Jena

et al. 2022

Therap Adv Gastroenterol

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Use of linked patient data to assess the effect of Long-COVID on system-wide healthcare utilisation

Murch

Hollier

Kenward

et al. 2022

HIM J

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Background: Within the relatively early stages of the COVID-19 pandemic, there had been an awareness of the potential longer-term effects of infection (so called Long-COVID) but little was known of the ongoing demands such patients may place on healthcare services. Objective: To investigate whether COVID-19 illness is associated with increased post-acute healthcare utilisation. Method: Using linked data from primary care, secondary care, mental health and community services, activity volumes were compared across the 3 months preceding and proceeding COVID-19 diagnoses for 7,791 individuals, with a distinction made between whether or not patients were hospitalised for treatment. Differences were assessed against those of a control group containing individuals who had not received a COVID-19 diagnosis. All data were sourced from the authors’ healthcare system in South West England. Results: For hospitalised COVID-19 cases, a statistically significant increase in non-elective admissions was identified for males and females <65 years. For non-hospitalised cases, statistically significant increases were identified in GP Doctor and Nurse attendances and GP prescriptions (males and females, all ages); Emergency Department attendances (females <65 years); Mental Health contacts (males and females ≥65 years); and Outpatient consultations (males ≥65 years). Conclusion: There is evidence of an association between positive COVID-19 diagnosis and increased post-acute activity within particular healthcare settings. Linked patient-level data provides information that can be useful to understand ongoing healthcare needs resulting from Long-COVID, and support the configuration of Long-COVID pathways of care.

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A comprehensive systematic scoping review for physiotherapy interventions for people living with long COVID

et al. 2023

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Background: A diverse spectrum of long COVID symptoms (LCS) have the scope of physical rehabilitation. Due to limited resources, very little is known about the physiotherapy and rehabilitation interventions for LCS and their clinical application. This study aims to explore the role of physiotherapy and rehabilitation interventions in the management of musculoskeletal, neurological, cognitive, cardiorespiratory, mental health, and functional impairments of LCS. Methods: The study was a systematic scoping review of the literature published between April 2020 and July 2022. Results: 87 articles were extracted followed by a standard process of The Preferred Reporting Items for Systematic reviews and meta-analysis (PRISMA) extension for Scoping reviews (PRISMA-ScR). The included studies had a 3223 LCS population. All types of primary and secondary articles were retrieved except for qualitative studies. The evidence was evaluated by an appraisal scoring tool followed by the guidelines of the “Enhancing the Quality and Transparency of health Research (EQUATOR) network”. The included papers had a mean appraisal score of 0.7807 on a 0 to 1 scale (SD 0.08), the minimum score was for study protocols (0.5870), and the maximum score was for Cohort studies (.8977). Sixty seven (67) evidence-based interventions were documented from 17 clinical categories. Conclusion: LCS can be treated by physiotherapy, exercise, and physical rehabilitation for musculoskeletal, neurological, cognitive, cardio-respiratory, mental health, and functional impairments at home or in clinical setups such as primary care settings by in-person care or telerehabilitation.

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S54 ‘Long-COVID’: the need for multi-disciplinary working

Cited by 7 publications

References 0 publications

Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

Use of linked patient data to assess the effect of Long-COVID on system-wide healthcare utilisation

A comprehensive systematic scoping review for physiotherapy interventions for people living with long COVID

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