S53P4 bioactive glass

Hulsen, Dennis Djw; Gestel, van Nap Nicole; Geurts, J. H. J.; Arts, Jacobus J.

doi:10.1016/b978-0-08-100205-6.00004-5

Cited by 9 publications

(7 citation statements)

References 75 publications

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“…From a clinical point of view, the larger S53P4 granules are more relevant than powder. For example in the treatment of osteomyelitis, usually bigger sized granules are used (Hulsen et al, 2017 ). Good clinical results have been obtained in the treatment of infections with the S53P4 granules (McAndrew et al, 2013 ; Geurts et al, 2016 ; Lindfors et al, 2016 ; Al Malat et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Growth Reduction of Five Clinical Pathogens by Injectable S53P4 Bioactive Glass Material Formulations

Thijssen

Gestel

Bevers

et al. 2020

Front. Bioeng. Biotechnol.

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The one-stage treatment of chronic osteomyelitis with S53P4 bioactive glass (BAG) granules has shown excellent results. However, these granules possess suboptimal handling properties. Therefore, new injectable S53P4 putty materials have been developed by the incorporation of a synthetic binder to contain glass granules. The goal of the current study was to assess their potential to eradicate five clinically relevant pathogens: methicillin sensitive Staphylococcus aureus (MSSA), methicillin resistant Staphylococcus aureus (MRSA), Enterococcus coli (E. coli), Enterococcus faecalis (E. faecalis), and Pseudomonas aeruginosa (P. aeruginosa). As a control, S53P4 granules (500-800 µm) and S66 glass (< 45 µm) were used. To evaluate the antimicrobial properties, the materials were cultured with the pathogens in a Müller-Hinton II broth for a week with daily colony forming unit (CFU) counting. One of the tested putty formulations was observed to reduce the number of CFU/mL compared to a negative control (no material, only pathogen in broth) for E. coli, E. faecalis and P. aeruginosa. However, none of the tested putty formulations was able to completely eradicate the pathogens in the broths, which would be needed for safe infection treatment. The results obtained for the control materials were unexpected. S66 glass showed full eradication of P. aeruginosa and reduced the number of CFUs of other pathogens, while the S53P4 granules did not show eradication. The observations on the loose S53P4 granules in this study contradict available literature, which needs further investigation. The results obtained in this study also stretch the importance for a better understanding of the underlying antimicrobial mechanism of S53P4 BAG and how this is related to the dosage. In addition, it should be elucidated how these antimicrobial properties are affected by changes in the material formulation, for example by addition of binders to improve the handling properties or by changing the surface area.

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Section: Discussionmentioning

confidence: 99%

Assessment of Growth Reduction of Five Clinical Pathogens by Injectable S53P4 Bioactive Glass Material Formulations

Thijssen

Gestel

Bevers

et al. 2020

Front. Bioeng. Biotechnol.

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“…This rapid response may be attributed to the rapid dissolution of the F18 glass particles on the surface of the fibers, releasing ions, such as Ca, Na, Si, and P to the medium. This ion leaching phenomenon was evaluated for F18 in several other studies [ 19 , 20 , 21 , 34 ] and is a well documented process for bioactive glasses in the literature [ 15 , 16 , 17 , 18 ]. These ionic products of bioactive glass dissolution are linked to an enhanced stimulation of cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…For example, Biosilicate ® is a composition that, when cryslized, is applicable as a substititute of small bones parts due to its improved machinability and mechanical strenght [ 18 ]. While S53P4 has been demonstrating good results in the treatment of osteomyelitis [ 19 , 20 , 21 ]. F18 glass, on the other hand, is a new composition designed to present a greater stability (when compared to 45S5) while keeping a high level of bioactivity, being a potential alternative for hard and soft tissue regeneration [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun F18 Bioactive Glass/PCL—Poly (ε-caprolactone)—Membrane for Guided Tissue Regeneration

et al. 2018

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Barrier membranes that are used for guided tissue regeneration (GTR) therapy usually lack bioactivity and the capability to promote new bone tissue formation. However, the incorporation of an osteogenic agent into polymeric membranes seems to be the most assertive strategy to enhance their regenerative potential. Here, the manufacturing of composite electrospun membranes made of poly (ε-caprolactone) (PCL) and particles of a novel bioactive glass composition (F18) is described. The membranes were mechanically and biologically tested with tensile strength tests and tissue culture with MG-63 osteoblast-like cell line, respectively. The PCL-F18 composite membranes demonstrated no increased cytotoxicity and an enhanced osteogenic potential when compared to pure PCL membranes. Moreover, the addition of the bioactive phase increased the membrane tensile strength. These preliminary results suggested that these new membranes can be a strong candidate for small bone injuries treatment by GTR technique.

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“…β‐tricalcium phosphate (β‐TCP) is a resorbable material that stimulates osteoconduction 4–6 . The second group of promising bioactive materials is represented by bioactive glasses, which have great biocompatibility and osteoinduction properties 7,8 . In particular, S53P4 bioactive glass (53% SiO 2 , 23% Na 2 O, 20% CaO, 4% P 2 O 5 —% wt) has shown great results as bone graft, especially for the treatment of osteomyelitis 7,9 .…”

Section: Introductionmentioning

confidence: 99%

“…The second group of promising bioactive materials is represented by bioactive glasses, which have great biocompatibility and osteoinduction properties 7,8 . In particular, S53P4 bioactive glass (53% SiO 2 , 23% Na 2 O, 20% CaO, 4% P 2 O 5 —% wt) has shown great results as bone graft, especially for the treatment of osteomyelitis 7,9 . This glass also showed angiogenic properties in some specific concentrations and particle sizes 10 .…”

Section: Introductionmentioning

confidence: 99%

3D‐printed β‐TCP/S53P4 bioactive glass scaffolds coated with tea tree oil: Coating optimization, in vitro bioactivity and antibacterial properties

et al. 2022

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Bone infection treatment is a significant challenge for the orthopedic field. 3D printing is a promising technology to produce scaffolds with customized architecture, able to stimulate and support bone growth. β-TCP and S53P4 bioactive glass (BG) are well-known biomaterials for scaffold manufacturing. However, a multifunctional scaffold, able to inhibit microbial proliferation at the defect site, is of increasing interest to avoid infection recurrence. Tea tree oil (TTO) has aroused interest as an antimicrobial agent to minimize the use of antibiotics. Therefore, combining the regenerative potential of a bioceramic with TTO's antimicrobial properties could result in a scaffold capable of stimulating tissue growth and treating infections. In this context, this study aimed to produce and characterize 3D-printed β-TCP/S53P4 BG scaffolds coated with TTO. Scaffolds morphological and chemical characterizations were carried out through XDR, SEM, and FTIR analysis. β-TCP/S53P4 BG scaffolds showed a compressive strength of $2 MPa and 53 ± 2% of porosity. The scaffolds were coated by two different procedures, using an ethanol/TTO (EtOH/TTO) and a gelatin/TTO (Gel/TTO) solution with 5, 10, and 15% (v/v) TTO. The addition of TTO decreased MG-63 cell viability for both coating groups, but the Gel/TTO group showed higher cell viability. The antibacterial activity of the coated scaffolds was evaluated against S. aureus and higher inhibition of colony formation was found for Gel/TTO group.Therefore, the coating with Gel/TTO was effective in terms of antibacterial activity and cell viability. Such Gel/TTO coated β-TCP/S53P4 BG scaffolds are proposed for antibacterial bone tissue engineering.

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S53P4 bioactive glass

Cited by 9 publications

References 75 publications

Assessment of Growth Reduction of Five Clinical Pathogens by Injectable S53P4 Bioactive Glass Material Formulations

Assessment of Growth Reduction of Five Clinical Pathogens by Injectable S53P4 Bioactive Glass Material Formulations

Electrospun F18 Bioactive Glass/PCL—Poly (ε-caprolactone)—Membrane for Guided Tissue Regeneration

3D‐printed β‐TCP/S53P4 bioactive glass scaffolds coated with tea tree oil: Coating optimization, in vitro bioactivity and antibacterial properties

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