“…Alpha-gal allergy is an emerging clinical syndrome, first described in the 2000s, that can cause gastrointestinal (GI) distress, hives, angioedema, and anaphylaxis hours after ingestion of pork, beef, and other mammalian meat or meat-derived products (1). Various publications in the allergy, GI, and general medicine literature have described patients with the allergy who present with GI-isolated symptoms without typical allergic symptoms such as angioedema or hives (2–8). Here, we aim to inform gastroenterologists on how to diagnose and manage alpha-gal allergy.…”