S3325 An SOS for SOS: A Case of Orthotopic Liver Transplantation in the Management of Hepatic Sinusoidal Obstruction Syndrome

Abstract

attacking the transplanted liver respectively. However, even with multi-modal therapy, the patient's condition worsened indicated by a rising MELD (model of end-stage liver disease) score and bilirubin concentration to 8 mg/dL. Discussion: We present a unique case of acute (antibody-mediated) rejection progressing to chronic rejection in a LDLT patient following pregnancy due to sensitization to donor HLA DQ6. Consistent posttransplant HLA antibody testing should be a consideration for LDLT patients for early detection and treatment of DSA before memory B-cell production allows rejection to become chronic. Testing is especially important for monitoring female patients with LDLTs from spouse due to risk of blood exposure during pregnancy.