S3 Guidelines for Colorectal Carcinoma

Schmiegel, Wolff; Pox, Christian; Reinacher-Schick, A.; Adler, Guido; Arnold, Dirk; Fleig, Wolfgang E.; Fölsch, U.R.; Frühmorgen, P.; Graeven, U.; Heinemann, Volker; Hohenberger, W.; Holstege, Axel; Junginger, Th.; Kopp, I.; Kühlbacher, T.; Porschen, Rainer; Propping, Peter; Riemann, J.F.; Rödel, Claus; Sauer, Rolf; Sauerbruch, T.; Schmitt, W; Schmoll, H.-J.; Seufferlein, Thomas; Zeitz, M.; Selbmann, H. K.

doi:10.1055/s-0028-1109936

Cited by 108 publications

(85 citation statements)

References 358 publications

(470 reference statements)

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“…If the family history of an individual includes one first degree relative and one second degree relative affected then the risk is one in 12. Current guidelines about the screening of CRC recommend starting at age 40 years in subjects with the increased risk (Winawer et al, 2003;Schmiegel et al, 2004). But, usually these subjects have inadequate interest to participate in screening programs.…”

Section: Discussionmentioning

confidence: 99%

Screening Colonoscopy Participation in Turkish Colorectal Cancer Patients and their First Degree Relatives

Kılıçkap¹,

Arslan²,

Rama³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: This study aimed to research the awareness of screening colonoscopy (SC) among patients with colorectal cancer (CRC) and their relatives. Methodology: A questionnaire form including information and behavior about colonoscopic screening for CRCs of patients and their first-degree relatives (FDRs) was prepared. Results: A total of 406 CRC patients were enrolled into the study, with 1534 FDRs (siblings n: 1381 and parents n: 153) . Positive family history for CRC was found in 12% of the study population. Previous SC was performed in 11% of patients with CRC. Mean age of the patients whose FDRs underwent SC was lower than the patients whose FDRs did not (52 vs 57 years; p<0,001). The frequency of SC in FDRs was 64% in patients diagnosed CRC under 35 years of age. Persons having a positive family history of CRC had SC more often (51 vs 22%, p<0,001). FDRs of patients having a higher educational level and income had SC more frequently. Conclusions: When screening for CRC is planned, elderly subjects, those with family history for CRC, and those with low educational and lower income should be given esspecial attention in order that they be convinced to undergo screening for CRC.

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Section: Discussionmentioning

confidence: 99%

Screening Colonoscopy Participation in Turkish Colorectal Cancer Patients and their First Degree Relatives

Kılıçkap¹,

Arslan²,

Rama³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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show abstract

“…Accordingly, FDRs (parent, sibling or child) of patients with CRC or adenomatous polyps are advised to have screening colonoscopy according to current guidelines which state that screening procedures should start at age 40 years or 10 years younger than the earliest diagnosis in their family, whichever comes first (Winawer et al, 2003;Schmiegel et al, 2004).…”

Section: Implementation Of Screening Colonoscopy Amongstmentioning

confidence: 99%

Implementation of Screening Colonoscopy amongst First-Degree Relatives of Patients with Colorectal Cancer in Turkey: a Cross-Sectional Questionnaire Based Survey

Adakan¹,

Taskoparan²,

Çekın³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Objective: To evaluate the implementation of screening colonoscopy amongst first-degree relatives (FDRs) of patients with colorectal cancer (CRC) in Turkey. Materials and Methods: A total of 400 first-degree relatives (mean(SD)age: 42.5(12.7) years, 55.5% were male) of 136 CRC patients were included in this cross-sectional questionnaire based survey. Data on demographic characteristics, relationship to patient and family history for malignancy other than the index case were evaluated in the FDRs of patients as were the data on knowledge about and characteristics related to the implementation of screening colonoscopy using a standardized questionnaire form.

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“…[1][2][3] More than 40% of CRC are located in the rectum. Although the local recurrence rate of rectal carcinoma is less than 10% after preoperative radiotherapy/ chemoradiotherapy and surgery based on total mesorectal excision, the development of distant metastases leads to a high rate of treatment failure of 30-35%.…”

mentioning

confidence: 99%

Rapid re-expression of CD133 protein in colorectal cancer cell lines in vitro and in vivo

Peickert

Waurig

Dittfeld

et al. 2012

Laboratory Investigation

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Studies related to the cancer stem cell hypothesis are challenging because of the imperfect tools to identify cell populations of interest and controversy on the usefulness of established cancer cell lines. We previously found CD133 to not be selective for a tumor-propagating or radioresistant population in a near-diploid, microsatellite-instable colorectal carcinoma (CRC) cell line. Because of discrepant literature data, we herein systematically analyzed the behavior of microsatellite-stable cell line subpopulations reflecting the more frequent carcinogenesis pathway in spontaneous CRC. CD133 þ and CD133 À /low populations were isolated by fluorescence-activated cell sorting and further processed. HT29 and SW620 cells were studied in detail in monolayer and/or spheroid culture assays and upon subcutaneous injection in NMRI (nu/nu) mice using a limiting dilution approach. CD133À /low HT29 cells showed a significantly lower clonogenic survival and reduced spheroid formation capacity than their CD133 þ counterparts. However, the cell populations neither differed in growth kinetics and response to treatment in vitro nor in tumor formation capacity when injecting as low as 10 cells. CD133 À /low HT29 cells rapidly re-expressed CD133 protein in vitro and in vivo as shown by flow cytometry and/or western blot analyses, and they also showed a particular survival benefit under tissue normoxic conditions. In contrast, CD133 protein in the CD133 þ population was quite stable throughout culturing. The observation of CD133 re-expression and lack of difference in tumor take rate of subpopulations was confirmed in SW620 cells. Here, we found cell density to affect CD133 re-expression in the CD133À -sorted population. And even SW480 cells, classified as a CD133 À cell line, presented some CD133 protein on their surface upon in vivo engraftment. We conclude that (i) CD133 protein expression shows high plasticity in CRC cell lines, and (ii) in vitro CD133 status on the cell surface neither determines tumorigenic potential nor CD133 profile in vivo.

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S3 Guidelines for Colorectal Carcinoma

Abstract: and the AWMF, representing the DGVS and the DKG Bibliography DOI http://dx.

Cited by 108 publications

References 358 publications

Screening Colonoscopy Participation in Turkish Colorectal Cancer Patients and their First Degree Relatives

Screening Colonoscopy Participation in Turkish Colorectal Cancer Patients and their First Degree Relatives

Implementation of Screening Colonoscopy amongst First-Degree Relatives of Patients with Colorectal Cancer in Turkey: a Cross-Sectional Questionnaire Based Survey

Rapid re-expression of CD133 protein in colorectal cancer cell lines in vitro and in vivo

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