S3.6 Effects of ganglioside sialidase inhibitors on proliferation and differentiation of human neuroblastoma cells

Production of recombinant human antithrombin III on 20-L bioreactor scale: Correlation of supernatant neuraminidase activity, desialylation, and decrease of biological activity of recombinant glycoprotein

“…On the other hand, addition of exogenous neuraminidase from Clostridium perfringens stimulated cell growth in different cell lines. Thus, the attempts to downregulate cellular neuraminidase activity should pay respect to possible growth stimulating functions of this enzyme (Cantz et al, 1993;Sweeley, 1993;. Cost-and/or time-consuming analytical methods of recombinant proteins, e.g., high performance anion exchange chromatography with pulsed amperometric detection (Townsend et al, 1989), enzyme array (Edge et al, Figure 5.…”