S2581 LAL-D: A Rare Liver Disease

Asafo-Agyei, Kwabena O.; Igbinedion, Samuel; Samant, Hrishikesh; Himes, Ryan

doi:10.14309/01.ajg.0000783856.61971.02

Cited by 30 publications

(32 citation statements)

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“…Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and a serious threat to human health, hindering social and economic development [ 1 , 2 ]. Currently, HCC is the fifth most common type of cancer worldwide [ 3 ]. HCC has a high mortality rate and is the second leading cause of cancer death [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

An immune subtype-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing analysis

Xie

Chen

Sun

et al. 2022

Aging

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Hepatocellular carcinoma (HCC) is one of the most common cancers in the world and is often associated with a poor prognosis. The main reason for this poor prognosis is that inconspicuous early symptoms lead to delayed diagnosis. Treatment options for advanced HCC remain limited and ineffective. In this context, the exploration of the immune microenvironment in HCC becomes attractive. In this study, we divided HCC into immune cell and non-immune cell subtypes, by single-cell sequencing analysis of GEO dataset GSE146115. We found differentially expressed genes in the two subtypes, which we used to construct a prognostic model for HCC through Cox and Lasso regressions. Our prognostic model can accurately evaluate the prognosis of HCC patients, and provide a reference for the design of immunotherapy for HCC.

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Section: Introductionmentioning

confidence: 99%

An immune subtype-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing analysis

Xie

Chen

Sun

et al. 2022

Aging

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“…Men are more likely than women to develop liver cancer, which is the fifth most frequently diagnosed cancer worldwide. In the UK, liver cancer in men is the 15th most common cancer, with nearly 4000 new cases being reported in 2017 2 …”

Section: What Is the Incidence Of Liver Cancer In Men?mentioning

confidence: 99%

“…The incidence of liver cancer is higher in men living in areas of socioeconomic deprivation. It is also on the rise, with incidence rates increasing by more than half in the last 10 years 2 …”

Section: What Is the Incidence Of Liver Cancer In Men?mentioning

confidence: 99%

Diagnosis and management of primary liver cancer in men

Raptis

Imber

2022

Trends Urol & Men's Health

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“…Hepatocellular carcinoma (HCC) is not only one of the most common cancers but also the second most frequent cause of cancer-related deaths worldwide ( 1 – 3 ). Recently, it has been reported that the proportion of elderly patients with HCC is increasing; meanwhile, more patients are diagnosed at an early stage, partly thanks to the advancement in screening programs ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Reminiscence Therapy as a Potential Method to Improve Psychological Health and Quality of Life in Elderly Hepatocellular Carcinoma Patients: A Randomized, Controlled Trial

Liu

et al. 2022

Front. Surg.

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BackgroundReminiscence therapy mitigates psychological issues and improves the quality of life of cancer survivors. However, its role in elderly patients with hepatocellular carcinoma (HCC) is unclear. Thus, we aimed to detect the effect of reminiscence therapy on anxiety, depression, and the quality of life of elderly patients with HCC.MethodsIn total, 106 elderly patients with HCC after resection were randomized in a 1:1 ratio to the reminiscence therapy group (N = 54) and control care group (N = 52) and then received intervention for 12 months. Anxiety and depression were evaluated by the Hospital Anxiety and Depression Scale (HADS) at baseline [Month (M) 0], 3 months (M3), 6 months (M6), 9 months (M9), and 12 months (M12). Meanwhile, quality of life was assessed using the European Organization for Research and Treatment of Cancer quality of life Questionnaire—Core 30 (QLQ-C30) at M0, M6, and M12.ResultsThe HADS for anxiety score at M9 (6.8 ± 2.3 vs. 7.8 ± 2.4, P = 0.039) and M12 (6.6 ± 2.4 vs. 7.8 ± 2.6, P = 0.013) and the anxiety proportion at M12 (27.8% vs. 46.2%, P = 0.050) were reduced in the reminiscence therapy group compared with those in the control care group. Moreover, the HADS for depression score declined at M9 (6.6 ± 2.0 vs. 7.5 ± 2.2, P = 0.025) and M12 (6.3 ± 2.3 vs. 7.7 ± 2.6, P = 0.005), but the proportion of those with depression was not different at each visit (P > 0.05) in the reminiscence therapy group compared with that of the control care group. In addition, the QLQ-C30 global health status score increased at M6 (71.3 ± 12.8 vs. 66.3 ± 12.9, P = 0.048) and M12 (74.5 ± 12.9 vs. 68.2 ± 13.3, P = 0.014) in the reminiscence therapy group compared to that in the control care group.ConclusionReminiscence therapy effectively mitigates anxiety and depression and improves the quality of life of elderly patients with HCC.

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S2581 LAL-D: A Rare Liver Disease

Cited by 30 publications

References 0 publications

An immune subtype-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing analysis

An immune subtype-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing analysis

Diagnosis and management of primary liver cancer in men

Reminiscence Therapy as a Potential Method to Improve Psychological Health and Quality of Life in Elderly Hepatocellular Carcinoma Patients: A Randomized, Controlled Trial

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