S224 Is There a Correlation Between Testosterone Levels and the Severity of the Disease in Male Patients With Obstructive Sleep Apnea?

Cangüven, Önder; Salepçi, Banu; Selimoglu, Ahmet; Balaban, Muhsin; Albayrak, Selami

doi:10.1016/s1569-9056(10)61508-4

Cited by 8 publications

(16 citation statements)

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“…These include a relatively low number of patients and the lack of the control group without SAS. However, previous studies have shown differences in testosterone between patients with and without SAS, and our study would not bring any novel information (Canguven et al ., ). The short duration of CPAP was not a limitation, as it was the aim of the study.…”

Section: Discussionmentioning

confidence: 97%

Short-term effects of continuous positive airway pressure on sex hormones in men and women with sleep apnoea syndrome

et al. 2013

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Patients with sleep apnoea syndrome (SAS) suffer from symptoms of hypogonadism. Besides surgical interventions, in some cases, the standard care of SAS for most patients is continuous positive airway pressure (CPAP). Studies focusing on the long-term effects of CPAP on testosterone levels revealed conflicting results. None of the studies included female patients with SAS. The aim of our study was to analyse and compare sex hormone levels in saliva before and after a night without and with CPAP in women and men with SAS. The results were negative. One night with CPAP did not affect the dynamics of sex hormones, neither in men nor in women. Future studies should focus on long-term effects of CPAP in both genders.

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Section: Discussionmentioning

confidence: 97%

Short-term effects of continuous positive airway pressure on sex hormones in men and women with sleep apnoea syndrome

et al. 2013

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“…Testosterone levels were higher in the OSA patients, but the differences between the groups were not statistically significant in this regard, which might have been due to the small sample size. Several studies have reported low serum testosterone in OSA patients . Nonetheless, testosterone has also been reported to increase following physical and psychosocial stress .…”

Section: Discussionmentioning

confidence: 99%

“…Testosterone is a sex hormone and the terminal part of the HPG axis. Several studies have found low serum testosterone levels in patients with OSA . The apnea‐hypopnea index (AHI) is one of the factors reported to be significantly associated with a low testosterone level among patients with severe OSA .…”

Section: Introductionmentioning

confidence: 99%

Serum testosterone/cortisol ratio in people with obstructive sleep apnea

Mohammadi

Rezaei

Sharafkhaneh

et al. 2019

Clinical Laboratory Analysis

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Objectives Obstructive sleep apnea (OSA) is a major health problem that has been associated with endocrine dysfunction in the hypothalamic‐pituitary‐gonadal (HPG) and hypothalamic‐pituitary‐adrenal (HPA) axes. This study investigated cortisol, testosterone, and the testosterone/cortisol ratio in patients with OSA compared to normal sleepers. Methods Thirty‐nine OSA patients diagnosed by overnight polysomnography (PSG) were divided into three groups, including ten mild OSA patients, 16 patients with moderate OSA, and 13 patients with severe OSA according to the apnea‐hypopnea index (AHI). In addition, 13 normal sleepers with normal PSG findings were recruited as the control group. Serum levels of cortisol, testosterone, and sex hormone‐binding globulin (SHBG) were measured using enzyme‐linked immunosorbent assay (ELISA). Results There were no significant differences between the normal sleepers and the three subtypes of OSA in terms of total and free testosterone levels (P > .1). The results showed significantly higher levels of cortisol in the severe OSA group compared to the normal sleepers and the two other subtypes of OSA (P < .01). In addition, the testosterone/cortisol (T/C) ratio was significantly lower among the severe OSA compared to the moderate OSA patients (P = .01). A significant correlation was observed between minimal SpO2 and AHI (r=−0.69, P < .01), cortisol and AHI (r = .47, P < .01) and cortisol and minimal SpO2 (r = −.26, P = .06). Conclusion According to the findings, OSA is linked to HPA axis activity in severe OSA patients but not among the mild and moderate subtypes of the disorder.

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“…35 One study suggested that measuring testosterone levels, which is easier than performing nocturnal polysomnography, may be useful for monitoring patients with OSA. 34 The incidence of OSA has been shown to be higher in men with reduced serum testosterone levels and in middleaged men. 4,36 This concept remains controversial.…”

Section: Discussionmentioning

confidence: 99%

“…Similar findings have been previously shown in obese but not overweight individuals. 30,31,34,38,41 The mechanisms by which oxygen desaturation influences testosterone levels are poorly understood and require further investigation. The circadian rhythm of testosterone may be affected in patients exposed to repetitive episodes of upper airway obstruction with marked sleep fragmentation as well.…”

Section: Discussionmentioning

confidence: 99%

Nocturnal Hypoxemia is Associated With Low Testosterone Levels in Overweight Males and Older Men With Normal Weight

Viana

Daflon

Couto

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives:The relationship among obstructive sleep apnea (OSA), body mass index (BMI), and testosterone levels has long been suggested. Obese men have shown a negative correlation between testosterone level and sleep apnea severity. Yet, little is known about the association between testosterone levels and sleep apnea in men who are not obese. This study evaluated the association between the total testosterone (TT) level and OSA in patients who are not obese. Methods: A retrospective review of 523 records of patients in whom OSA was diagnosed from 2013-2016 was performed. The study included men with a BMI < 30 kg/m 2 and with TT levels measured in a blood sample collected the morning after a sleep study. Results: In all, 153 nonobese men met inclusion criteria, of whom 47 (30.7%) had testosterone levels below the reference values; 44 of these individuals (93.6%) were overweight (P = .029). Reduced testosterone levels showed significant correlations with the oxygen desaturation index, the lowest oxygen saturation < 80% (O2 nadir < 80%), and rapid eye movement (REM) sleep duration, after adjusting for BMI. Among patients with normal weight, only 3 who had O2 nadir < 80% and were older than 50 years presented with a reduced TT level. Conclusions:In a large population of nonobese men with OSA, we demonstrated that hypoxemia (O2 nadir < 80%) and overweight are associated with reduced testosterone levels. This association was only observed among normal-weight individuals older than 50 years. Keywords: body mass index, hypoxia, obstructive sleep apnea, sex hormone, testosterone Citation: Viana A Jr, Daflon AC, Couto A, Neves D, de Araujo-Melo MH, Capasso R. Nocturnal hypoxemia is associated with low testosterone levels in overweight males and older men with normal weight. J Clin Sleep Med. 2017;13(12):1395-1401. I NTRO DUCTI O NProgressive decreases in androgen production are observed in at least 20% of males aged 60 to 70 years.1 Total testosterone (TT) levels were found to be stable in men up to the ages of 50 to 55 years, while a reduction in TT of approximately 35% has been described in males between the ages of 25 and 75 years. 2,3 In healthy patients aged 20 to 100 years, subnormal levels of TT and free testosterone were observed in only 1% of the population younger than 40 years, whereas this percentage increased to more than 10%, 20%, and 40% in those aged 40-60 years, 60-80 years, and older than 80 years, respectively.2 Hypogonadal testosterone levels have been found in approximately 12% of men older than 50 years and in 50% of men older than 80 years. 4,5 The etiology of this testosterone decline is multifactorial and involves disturbed neuroendocrine gonadotropin regulation. 1,6 Obstructive sleep apnea (OSA) is a common disorder. In men 40-49 years old, the prevalence of apnea-hypopnea index [AHI] ≥ 5 events/h has been reported at 25%; furthermore, in this same age group, the prevalence of AHI ≥ 15 events/h has been reported at 11%.7 Peppard et al. reported that, among overweight men, the prevalence o...

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S224 Is There a Correlation Between Testosterone Levels and the Severity of the Disease in Male Patients With Obstructive Sleep Apnea?

Cited by 8 publications

References 0 publications

Short-term effects of continuous positive airway pressure on sex hormones in men and women with sleep apnoea syndrome

Short-term effects of continuous positive airway pressure on sex hormones in men and women with sleep apnoea syndrome

Serum testosterone/cortisol ratio in people with obstructive sleep apnea

Nocturnal Hypoxemia is Associated With Low Testosterone Levels in Overweight Males and Older Men With Normal Weight

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