S2141 Systemic Mastocytosis Presented as Subtle Colonic Mucosa Change

Abstract

Figure 1. A-B: Biopsy of both polyps showed polypoid colonic mucosa with a lamina propria expanded by atypical clusters of spindled mast cells and prominent background eosinophilia. C: Immunohistochemistry for C-kit/CD117 confirmed a marked increase in clustered and spindled mast cells. D: CD25 was also positive in the mast cells, a marker typically positive in systemic mastocytosis. E: Cecal picture with very subtle nodularity change. F: NBI picture of nodularity change in cecum.