S212 Incidence Rates of Adenoamtous Polyps, Clinically Significant Serrated Polyps and Advanced Neoplasia in Adults Age 18-45 in a Community Hospital in the Upper Midwest Over a 15-Year Period: A Retrospective Review

Abstract

Methods: We employed a multi-institutional database (Explorys Inc., Cleveland, OH); an aggregate of electronic health record data from 26 major US health systems. We formed cohorts of patients with CD and MC using Systemized Nomenclature of Medicine -Clinical Terms (SNOMED -CT). Microscopic colitis was defined as SNOMED terms "microscopic colitis" or "collagenous colitis." Univariate and multivariate analyses were performed on the data, and associations were reported as adjusted odds ratios (aORs) with 95% confidence intervals (CIs) using IBM SPSS Statistics version 28. Results: Of 47,900,300 adult patients in the database, 143,290 (0.30%) carried a celiac disease diagnosis. Among CD patients, 70 (0.05%) carried a microscopic colitis diagnosis compared to 143,220 (99.95%) of the non-CD patients (p , 0.0001). After multivariate analysis, celiac disease was associated with an increased odds of microscopic colitis (aOR 5 10.5; 95% CI 8.59-12.94; p 5 , 0.0001) (Table ). Conclusion: This large population-based cohort study demonstrated significantly higher odds of MC among patients with celiac disease compared to patients without the disease with higher odds in females, older individuals, smokers, use of NSAIDs and PPIs. Our findings are in line with those from previous observational studies showing the same. Larger prospective studies would be beneficial in identifying the role of gluten exposure in development of microscopic colitis in patients with celiac disease.