S2067 ICC and Slow Wave Propagation in the Small Intestine of Diabetic Rats

Lammers, Wim J. E. P.; Al-Bloushi, Hanifa M.; Al-Eisaei, Shaikha; Al-Dhaheri, Fatima; Stephen, Betty; John, Rony; Dhanasekaran, Sekar; Karam, Sherif M.

doi:10.1016/s0016-5085(10)61439-4

Cited by 4 publications

(5 citation statements)

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“…Lammers et al . suggested that as much as 35% loss may be required to affect ICC-MP slow wave activity in the small intestine 66 . More research is needed to substantiate this for all networks and in the colon.…”

Section: Discussionmentioning

confidence: 99%

Intraluminal pressure patterns in the human colon assessed by high-resolution manometry

Chen

Yang

et al. 2017

Sci Rep

104

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Assessment of colonic motor dysfunction is rarely done because of inadequate methodology and lack of knowledge about normal motor patterns. Here we report on elucidation of intraluminal pressure patterns using High Resolution Colonic Manometry during a baseline period and in response to a meal, in 15 patients with constipation, chronically dependent on laxatives, 5 healthy volunteers and 9 patients with minor, transient, IBS-like symptoms but no sign of constipation. Simultaneous pressure waves (SPWs) were the most prominent propulsive motor pattern, associated with gas expulsion and anal sphincter relaxation, inferred to be associated with fast propagating contractions. Isolated pressure transients occurred in most sensors, ranging in amplitude from 5–230 mmHg. Rhythmic haustral boundary pressure transients occurred at sensors about 4–5 cm apart. Synchronized haustral pressure waves, covering 3–5 cm of the colon occurred to create a characteristic intrahaustral cyclic motor pattern at 3–6 cycles/min, propagating in mixed direction. This activity abruptly alternated with erratic patterns resembling the segmentation motor pattern of the small intestine. High amplitude propagating pressure waves (HAPWs) were too rare to contribute to function assessment in most subjects. Most patients, dependent on laxatives for defecation, were able to generate normal motor patterns in response to a meal.

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Section: Discussionmentioning

confidence: 99%

Intraluminal pressure patterns in the human colon assessed by high-resolution manometry

Chen

Yang

et al. 2017

Sci Rep

104

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“…This concept was further investigated in a cellular automaton model of the small intestine (Lammers et al . ). In that model, it was shown that random small deletion of individual cells had little effect on overall propagation pattern and velocity of propagation.…”

Section: Slow Wave Arrhythmias In the Small Intestinementioning

confidence: 97%

“…The difference with Seidel's observation could be due to a point raised by Huizinga (1998) that one advantage of ICC-MY being organized in a network could be that damage to a few cells could be corrected by the rest of the network. This concept was further investigated in a cellular automaton model of the small intestine (Lammers et al 2011). In that model, it was shown that random small deletion of individual cells had little effect on overall propagation pattern and velocity of propagation.…”

Section: Slow Wave Arrhythmias In the Small Intestinementioning

confidence: 99%

Normal and abnormal electrical propagation in the small intestine

Lammers

2014

Acta Physiol

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As in other muscular organs, small intestinal motility is determined to a large degree by the electrical activities that occur in the smooth muscle layers of the small intestine. In recent decades, the interstitial cells of Cajal, located in the myenteric plexus, have been shown to be responsible for the generation and propagation of the electrical impulse: the slow wave. It was also known that the slow waves as such do not cause contraction, but that the action potentials ('spikes') that are generated by the slow waves are responsible for the contractions. Recording from large number of extracellular electrodes simultaneously is one method to determine origin and pattern of propagation of these electrical signals. This review reports the characteristics of slow wave propagation through the intestinal tube, the occurrence of propagation blocks along its length, which explains the well-known decrease in frequency, and the specific propagation pattern of the spikes that follow the slow waves. But the value of high-resolution mapping is highest in discovering and analysing mechanisms of arrhythmias in the gut. Most recently, circus movements (also called 're-entries') have been described in the small intestine in several species. Moreover, several types of re-entries have now been described, some similar to what may occur in the heart, such as functional re-entries, but others more unique to the small intestine, such as circumferential re-entry. These findings seem to suggest the possibilities of hitherto unknown pathologies that may be present in the small intestine.

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“…In rodent models, however, changes in ICC morphology could also be observed in the proximal and distal colon. However, slow wave frequencies, velocities and extracellular amplitudes were unchanged in a recent study with streptozotocin treated diabetic rats (Lammers et al, 2011), challenging the hypothesis that ICC reduction is severe enough to effect slow wave propagation in the bowel.…”

Section: Diabetic Gastroenteropathymentioning

confidence: 86%

The Role of Interstitial Cells of Cajal (ICC) in Gastrointestinal Motility Disorders - What the Gastroenterologist Has to Know

Breuer¹

2012

Constipation - Causes, Diagnosis and Treatment

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S2067 ICC and Slow Wave Propagation in the Small Intestine of Diabetic Rats

Cited by 4 publications

References 0 publications

Intraluminal pressure patterns in the human colon assessed by high-resolution manometry

Intraluminal pressure patterns in the human colon assessed by high-resolution manometry

Normal and abnormal electrical propagation in the small intestine

The Role of Interstitial Cells of Cajal (ICC) in Gastrointestinal Motility Disorders - What the Gastroenterologist Has to Know

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