S1859 Serum Cytokeratin 18 and Adipocytokines in Alcoholic Hepatitis Versus Nonalcoholic Steatohepatitis

Zewdu, Manny C.; Henry, LaTasha; Falkner, K. Cameron; McClain, Craig J.; Cave, Matthew C.

doi:10.1016/s0016-5085(10)63706-7

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the CK18 M30:M65 ratio in ABS workers suspected of having TASH was 33%. This relatively low ratio was consistent with that observed in our cohort of biopsy-proven vinyl chloride-related TASH (26%), and is much lower than the ratios historically reported in adult (55%) and pediatric (59%) obesity-related NASH studies (1, 22, 27), as well as alcoholic hepatitis (28). Interestingly, although the absolute levels of both CK18 M30 and M65 were normal in group 1, the CK18 M30:M65 ratio was lower than healthy controls from our previous study who did not work in the chemical industry and thus did not have high-level industrial chemical exposures (33% vs. 76%) (1).…”

Section: Discussionsupporting

confidence: 90%

Serum Cytokeratin 18 and Cytokine Elevations Suggest A High Prevalence of Occupational Liver Disease in Highly Exposed Elastomer/Polymer Workers

Cave

Falkner

Henry

et al. 2011

Journal of Occupational &Amp; Environmental Medicine

Self Cite

View full text Add to dashboard Cite

Objective Cytokeratin 18 (CK18) is a novel serologic biomarker for occupational liver disease. The purpose of this study is to determine the prevalence of CK18 elevation in elastomer/polymer workers exposed to acrylonitrile, 1,3 butadiene, and styrene. Methods 82 chemical workers were evaluated. CK18 was determined by ELISA and pro-inflammatory cytokines were measured by multi-analyte chemiluminescent detection. Results 39% (32 of 82) had elevated CK18 levels which were not explained by alcohol or obesity, except in potentially 4 cases. The pattern of CK18 elevation was consistent with toxicant-associated steatohepatitis (TASH) in the majority of cases (78%). TNFα, IL-6, IL-8, MCP-1, and PAI-1 were increased in these workers compared to those with normal CK18 levels. Conclusions These results suggest a high prevalence of occupational liver disease and TASH in elastomer/polymer workers with elevated pro-inflammatory cytokines.

show abstract