S178 A Systematic Review of the Gut Microbiota Profile in Patients With Heart Failure

Simadibrata, Daniel Martin; Auliani, Salwa; Widyastuti, Putu Ayu; Wijaya, Andi; Amin, Hilman Zulkifli; Muliawan, Hary Sakti; Siswanto, Bambang Budi; Simadibrata, Marcellus

doi:10.14309/01.ajg.0000857352.83593.b6

Cited by 2 publications

(3 citation statements)

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“…COVID-19 progression and severity are associated with changes in the gut microbiota following SARS-CoV-2 infection, which may be caused by changes in the abundance of key bacterial groups that are associated with host immune dysregulation. 10,[74][75][76] SARS-CoV-2 recognizes and invades cells through ACE2 and may affect immune and metabolic functions. The ACE2 receptor is highly expressed on intestinal cells, which are an important site for virus entry into the intestine.…”

Section: Alterations In Gut Microbiotamentioning

confidence: 99%

“…Furthermore, correlation analysis suggested that the abundance of harmful bacteria, such as Enterobacteriaceae , was correlated with the severity of symptoms. COVID‐19 progression and severity are associated with changes in the gut microbiota following SARS‐CoV‐2 infection, which may be caused by changes in the abundance of key bacterial groups that are associated with host immune dysregulation 10,74–76 . SARS‐CoV‐2 recognizes and invades cells through ACE2 and may affect immune and metabolic functions.…”

Section: Dynamic Changes Of Microbiota In Covid‐19mentioning

confidence: 99%

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Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Qiu,

Mo,

Chen

et al. 2024

MedComm

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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 million deaths. Patients with coronavirus disease (COVID‐19) may suffer from diarrhea, sleep disorders, depression, and even cognitive impairment, which is associated with long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients with COVID‐19 have alterations in microbiota and their metabolites, particularly in the gut, which may be involved in the regulation of immune responses. Consumption of probiotics may alleviate the discomfort caused by inflammation and oxidative stress. However, the pathophysiological process underlying the alleviation of COVID‐19‐related symptoms and complications by targeting the microbiota remains unclear. In the current study, we summarize the latest research and evidence on the COVID‐19 pandemic, together with symptoms of SARS‐CoV‐2 and vaccine use, with a focus on the relationship between microbiota alterations and COVID‐19‐related symptoms and vaccine use. This work provides evidence that probiotic‐based interventions may improve COVID‐19 symptoms by regulating gut microbiota and systemic immunity. Probiotics may also be used as adjuvants to improve vaccine efficacy.

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Section: Alterations In Gut Microbiotamentioning

confidence: 99%

Section: Dynamic Changes Of Microbiota In Covid‐19mentioning

confidence: 99%

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Qiu,

Mo,

Chen

et al. 2024

MedComm

View full text Add to dashboard Cite

show abstract

“…As knowledge emerges from investigations elucidating the gut-brain, 1 gut-heart, 2 gut-kidney, 3 and gut-immune axes, 4 it is becoming increasingly clear that the multitude of microbes, microbial interactions, microbe-derived metabolites, and microbial genes that reside within the mammalian gut play a key and contributory role in determining the occurrence, course, and outcome from disease 5 . The recent description of an “ecologic memory” of the gut microbiome suggests that one's life history or “exposome” may be reflected in a multidimensional and comprehensive interrogation of one's gut microbiome 6–8 .…”

mentioning

confidence: 99%

Social determinants of health, the microbiome, and surgical injury

Alverdy,

Polcari,

Benjamin

2024

J Trauma Acute Care Surg

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Post-injury infection continues to plague trauma and emergency surgery patients fortunate enough to survive the initial injury. Rapid response systems, massive transfusion protocols, the development of level 1 trauma centers, etc., have improved the outcome for millions of patients worldwide. Yet despite this excellent initial care, patients still remain vulnerable to post-injury infections that can result in organ failure, prolonged critical illness and even death. While risk factors have been identified (degree of injury, blood loss, time to definitive care, immunocompromise, etc.) they remain probabilistic, not deterministic, and do not explain outcome variability at the individual case level. Here, we assert that analysis of the social determinants of health, as reflected in the patient’s microbiome composition (i.e. community structure, membership) and function (metabolomic output), may offer a “window” with which to define individual variability following traumatic injury. Given emerging knowledge in the field, a more comprehensive evaluation of biomarkers within the patient’s microbiome, from stool-based microbial metabolites to those in plasma and those present in exhaled breath, when coupled with clinical metadata and machine learning, could lead to a more deterministic assessment of an individual’s risk for a poor outcome and those factors that are modifiable. The aim of this piece is to examine how measurable elements of the social determinants of health and the life-history of the patient may be buried within the ecologic memory of the gut microbiome. Here we posit that interrogation of the gut microbiome in this manner may be used to inform novel approaches to drive recovery following a surgical injury.

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S178 A Systematic Review of the Gut Microbiota Profile in Patients With Heart Failure

Cited by 2 publications

References 0 publications

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Social determinants of health, the microbiome, and surgical injury

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