S1755 Oxytocin Treatment Alleviates Stress-Aggravated Colitis By a Receptor-Dependent Mechanism

Treatment with oestrogen‐receptor agonists or oxytocin in conjunction with exercise protects against myocardial infarction in ovariectomized rats

“…It was demonstrated in rats with myocardial I/R that OT pretreatment reduces myocardial infarct size and ventricular arrhythmias via nitric oxide production and protein kinase C activation and by maintaining the oxidant-antioxidant balance . In parallel with that, we have previously shown that OT ameliorates oxidative renal or colonic damage through its antioxidant effect by inhibition of the free radical waterfall cascade and secretion of cytokines (Tugtepe et al 2007;Ç etinel et al 2010). Based on the structure of the OTR gene promoter region, it has been proposed that the pro-inflammatory cytokines may function as negative modulators of OTR gene transcription (Sidaway, 2015).…”

“…In contrast, the cardioprotective effects of regular exercise, verified by several epidemiological studies (Shephard & Balady, 1999;Lavie et al 2009), appear to involve the upregulation of the cardiac OT and ANP systems (Gutkowska et al 2007) and increased hypothalamic OT content and gene expression (Braga et al 2000;Martins et al 2005). Furthermore, in several inflammatory models, including myocardial injury in heart transplant, OT was shown to exert protective effects through the downregulation of inflammatory and oxidative processes (Tugtepe et al 2007;Ç etinel et al 2010;Al-Amran & Shahkolahi, 2014). No data are present regarding the anti-inflammatory effects of OT on menopause-associated myocardial injury.…”