S1581 Development of Ex Vivo and In Vivo Models to Assess the Performance of an Oral Biotherapeutic Delivery System Capsule

Abstract

Figure 1. A) Alpha-diversity box plots comparing the duodenal microbial diversity in the Tonsillectomy group (T1), and the no Tonsillectomy group (T-), as determined using 3 different indices, Shannon's, Simpson's and Chao1. B) Principal Component Analysis (PCA) plot of the duodenal microbiome beta-diversity of Tonsillectomy group (T1) compared to no Tonsillectomy group (T-). C) Heat tree illustrating minimal changes to the microbiome in subjects who reported undergoing a tonsillectomy (T1) relative to those who did not (T-). Nodes represent taxonomic levels, and greater line thickness denotes greater relative abundance. Taxa with higher relative abundance in the T1 group when compared to the T-group are shown in red. Taxa with higher relative abundance in the T-group when compared to the T1 group are shown in blue. Taxa with similar relative abundance in both groups are shown in gray