S1507 Disconnected Pancreatic Duct Syndrome: To Drain or Not to Drain?

Uhlenhopp, Dustin; Sunkara, Tagore; Gaduputi, Vinaya

doi:10.14309/01.ajg.0000708076.03587.11

Cited by 2 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, ESCC remains the most predominant kind globally. Despite progress in incipient diagnosis and immune treatment, esophageal squamous cell carcinoma is often detected at a later stage with a disappointing prediction (Uhlenhopp et al, 2020). The treatment of many diseases covers LATS2.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Identifying LATS2 as a prognostic biomarker relevant to immune infiltrates in human esophageal squamous cell carcinoma

et al. 2022

View full text Add to dashboard Cite

According to the TIMER database, large tumor suppressor 2 (LATS2) is differentially expressed in various tumors. However, the correlation between LATS2 and esophageal squamous cell carcinoma (ESCC) and the association between LATS2 and immune infiltration in ESCC remain unclear. Our synthetic research on LATS2 in ESCC revealed that the expression was low in esophageal squamous epithelium tissues, revealing the pernicious and adverse prognosis of ESCC. The Kaplan–Meier survival investigation pointed out that low LATS2 expression would result in an adverse prognosis. Biological investigation indicated that LATS2 was engaged in cell migration, adhesion, and junction. To further explore the relationship between LATS2 and tumor immunity, we utilized CIBERSORT to assess immune infiltration. The findings revealed that specimens with lower LATS2 expression showed higher immune infiltration, including T-cell follicular helper cells, M0 macrophages, M1 macrophages, and myeloid dendritic cell resting. An association investigation indicated that LATS2 was negatively relevant to immune checkpoints that restrain operative antitumor immune reactions. We also conducted immunohistochemical staining to explore the link between LATS2 expression and immunophenotype. The indicated association between low LATS2 expression and an immunophenotype is conducive to our understanding of ESCC mini-environments and might offer new indications for enhancing new therapeutic targets.

show abstract

Section: Discussionmentioning

confidence: 99%

“…It manifests as a poor prognosis during diagnosis and a high mortality ratio. Its main subtypes are ESCC and adenocarcinoma, of which the former is the most commonly seen (Uhlenhopp et al, 2020). The operative early tumor markers and diagnostic approaches for esophageal squamous cell carcinoma are still insufficient.…”

Section: Introductionmentioning

confidence: 99%

Identifying LATS2 as a prognostic biomarker relevant to immune infiltrates in human esophageal squamous cell carcinoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…EC comprises two primary histological types, esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), which differ in etiology and geography. The risk factors of EAC primarily include obesity, gastroesophageal reflux disease (GERD), and Barrett's esophagus, and the increase in these risk factors in populations of high-income countries contributes to the high prevalence of EAC, accounting for approximately two-thirds of EC cases (Blot et al, 2018;Uhlenhopp et al, 2020). Barrett's esophagus is characterized by the presence of a precancerous lesion and the induction of columnar metaplasia in the normal squamous epithelium owing to injury resulting from GERD in the distal esophagus (Clermont and Falk, 2018).…”

mentioning

confidence: 99%

“…However, in countries with a lower income, ESCC accounts for approximately 90% of patients with EC. Smoking, nitrosamine intake, dietary habits such as preference for hot food, pickled vegetables, and high alcohol consumption are important factors leading to ESCC (Uhlenhopp et al, 2020). The pathogenesis of EC has not been completely elucidated, and the occurrence of EC may result from the long-term interaction between genetic factors and environmental factors.…”

mentioning

confidence: 99%

“…The pathogenesis of EC has not been completely elucidated, and the occurrence of EC may result from the long-term interaction between genetic factors and environmental factors. However, despite extensive progress in research on the diagnosis and treatment of EC, its morbidity and mortality rates are still on the rise, and the 5-year survival rate remains low (Uhlenhopp et al, 2020).…”

mentioning

confidence: 99%

See 1 more Smart Citation

The anticancer effects of curcumin and clinical research progress on its effects on esophageal cancer

Wang

Gao

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Esophageal cancer (EC) is a common tumor of the gastrointestinal system and a major threat to human health. The etiology and incidence of EC vary depending on the type of pathology. Owing to the unique physiological structure of the esophagus and the poor biological behavior of EC, the treatment modalities available are limited, and the prognosis of patients is relatively poor. Curcumin is a type of natural phytochemical belonging to the class of phenolic compounds. It exerts favorable anticancer effects on various cancers. A growing body of evidence indicates that curcumin suppresses tumor development and progression by inhibiting tumor cell proliferation, invasion, and migration, thus inducing apoptosis, regulating microRNA expression, reversing multidrug resistance, and inducing sensitivity to the therapeutic effect of chemoradiotherapy. Multiple cellular molecules, growth factors, and genes encoding proteins participating in different signaling pathways interact with each other to contribute to the complex and orderly anticancer effect. The efficacy and safety of curcumin have been established in preclinical studies for EC and clinical trials for other cancers. However, the low bioavailability of curcumin limits its clinical application. Therefore, the modification of curcumin analogs, the combination of curcumin with other drugs or therapies, and the use of novel nanocarriers have been widely investigated to improve the clinical effects of curcumin in EC.

show abstract

S1507 Disconnected Pancreatic Duct Syndrome: To Drain or Not to Drain?

Cited by 2 publications

References 0 publications

Identifying LATS2 as a prognostic biomarker relevant to immune infiltrates in human esophageal squamous cell carcinoma

Identifying LATS2 as a prognostic biomarker relevant to immune infiltrates in human esophageal squamous cell carcinoma

The anticancer effects of curcumin and clinical research progress on its effects on esophageal cancer

Contact Info

Product

Resources

About