S142: Deciphering the Complexity of T Cells in Blood and Lymph Nodes of Patients With CLL by Integrative Single-Cell Rna-Seq and Mass Cytometry Analyses

Abstract

Background: Background:Abnormal distribution and impaired function of T cells are key features of chronic lymphocytic leukemia (CLL), a malignancy of mature B lymphocytes that develops in secondary lymphoid tissue and blood. These defects have been linked to failure of immune control and resistance to immunotherapy including immune checkpoint or CAR T-cell therapy. A better characterization of T cells and their loss of function in CLL will help to improve such treatment approaches.